Kristina Nagy

Accomplished Senior Scientist with a robust track record at the Mount Sinai Hospital Research Institute and panCELLa, a biotech spin-off company. Rigorous experience in genetic engineering CRISPR/CAS9) and advanced cell culture (ESC and iPSC). Extensive experience with manuscript writing and grant applications. Proven expertise in experimental design and project management.

Book chapters

Beringer RR, Gertsenstein M, Nagy K, Nagy A. Manipulating the Mouse Embryo. A Laboratory Manual.

Cold Spring Harbour Press, (4rdedition) 2014

Nagy A, Nagy K, Gertsenstein M. Production of mouse chimeras by aggregating pluripotent stem cells with embryos.

Methods in Enzymology. 2010;476;123-49

Tanaka M, Hadjantonakis AK, Vintersten K, Nagy A. Aggregation chimeras: combining ES cells, diploid, and tetraploid embryos.

Methods in Molecular Biology. 2009;530:287-309

Vintersten K, Testa G, Naumann R, Anastassiadis K, Stewart AF. Bacterial artificial chromosome transgenesis through pronuclear injection of fertilized mouse oocytes.

Methods in Molecular Biology. 2008;415:83-100

Nagy A, Vintersten K.Murine embryonic stem cells.

Methods Enzymol. 2006;418:3-21.

Vintersten K, Testa G, Stewart AF.  Microinjection of BAC DNA into the pronuclei of fertilized mouse oocytes.

Methods Mol Biol. 2004;256:141-58.

Testa G, Vintersten K, Zhang Y, Benes V, Muyrers JP, Stewart AF. BAC engineering for the generation of ES cell-targeting constructs and mouse transgenes.

Methods Mol Biol. 2004;256:123-39.

Maatman R, Gertsenstein M, de Meijer E, Nagy A, Vintersten K. Aggregation of embryos and embryonic stem cells.

Methods Mol Biol. 2003;209:201-30.

Nagy A, Gertsenstein M, Vintersten K, Beringer RR. Manipulating the Mouse Embryo. A Laboratory Manual.

Cold Spring Harbour Press, 2002. (3rdedition)

Scientific articles

Harding J, Vintersten-Nagy K, wt.al.  Immune-priviledged tissues formed from immunologically cloaked mouse embryonic stem cells survive long term in allogeneic hosts.  Nat Biomed Eng 2023. Nov 23. doi: 10.1038/s41551-023-01133-y.  PMID: 37996616

Harding J, Vinterstein-Nagy K, Nagy A.  (2020) Universal Stem Cells: making the unsafe safe.  Cell Stem Cell.  2020. Aug 6, 27(2): 198-9. Letter re: Gonzalez BJ et al, (Cell Stem Cell 26:307-308, March 5, 2020).  PMID: 32763181

Massumi M, Pourasgari F, Nalla A, Batchuluun B, Nagy K et al. An Abbreviated Protocol for In Vitro Generation of Functional Human Embryonic Stem Cell-Dervied Beta-Like Cells. PLoS One. 2016 Oct 18;11(10)

Lepage SI, Nagy K, Sung HK, Kandel R, Nagy A, Koch TG. Generation, characterization and multi-lineage potency of mesenchymal-like progenitors derived from equine induced pluripotent stem cells. Stem Cells Dev. 2016 Jan 1:25(1):80-9.

Nagy K, Nagy A. (2015) Derivation of Equine-Induced Pluripotent Stem Cell Lines Using a piggyBac Transposon Delivery System and Temporal Control of Transgene Expression. Methods Mol Biol. 2015; 1330: Chapter 8 pages 79-88. PMID: 26621591

Scheff M, Chau GC, Vintersten K, Mueller M, Gangloff YG, Adams RH, Spetz JF, Elghazi L, Pfluger PT, Pende M, Bernal-Mizrachi E, Tauler A, Tschöp MH, Thomas G, Kozma SC. S6K1 controls pancreatic β cell size independently of intrauterine growth restriction. J Clin Invest. 2015 Jul 1;125(7):2736-47.

Sung HK, Doh KO, Son JE, Park JG, Bae Y, Choi S, Nelson SML, Cowling R, Nagy K, Michael IP, Koh GY, Adamson SL, Pawson A, Nagy A. Adipose Vascular Endothelial Growth Factor Regulates Metabolic Homeostasis through Angiogenesis.

Cell Metabolism. 2013, 17(1),:61-72

Hussein SM, Nagy K, Nagy A. Human Induced Pluripotent Stem Cells: The Past, Present, and Future.

Clinical Pharmacology & Therapeutics 2011 May;89(5):741-5

Nagy K, Sung HK, Zhang P, Laflamme S, Vincent P, Agha-Mohammadi S, Woltjen K, Monetti C, Michael IP, Smith LC, Nagy A. (2011) Induced Pluripotent Stem Cell Lines Derived from Equine Fibroblasts. Stem Cell Rev. 2011 Sep;7(3):693-702

Nagy A, Nagy K.The mystery of induced pluripotency: where will they lead?

Nature Methods 2010 Jan;7(1):22-4

Gertsenstein M, VinterstenK. The 7th Transgenic Technology meeting: debut for “down under”

Transgenic Research 2007 Oct;16(5):671-3.

Sophia H. L. George, Marina Gertsenstein, Kristina Vintersten, Ella Korets-Smith, John Murphy, Mary E. Stevens, Jody J. Haigh, and Andras Nagy. Developmental and adult phenotyping directly from mutant embryonic stem cells.

Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4455-60

Angrand PO, Segura I, Volkel P, Ghidelli S, Terry R, Brajenovic M, Vintersten K, Klein R, Superti-Furga G, Drewes G, Kuster B, Bouwmeester T, Acker-Palmer A.Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.

Mol Cell Proteomics. 2006 Dec;5(12):2211-27.

Glaser S, Schaft J, Lubitz S, Vintersten K, van der Hoeven F, Tufteland KR, Aasland R, Anastassiadis K, Ang SL, Stewart AF. Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development.

Development. 2006 Apr;133(8):1423-32.

Vintersten K, Monetti C, Gertsenstein M, Zhang P, Laszlo L, Biechele S, Nagy A. Mouse in red: red fluorescent protein expression in mouse ES cells, embryos, and adult animals.

Genesis. 2004 Dec;40(4):241-6.

Michos O, Panman L, Vintersten K, Beier K, Zeller R, Zuniga A. Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis.

Development. 2004 Jul;131(14):3401-10.

Zuniga A, Michos O, Spitz F, Haramis AP, Panman L, Galli A, Vintersten K, Klasen C, Mansfield W, Kuc S, Duboule D, Dono R, Zeller R. Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression.

Genes Dev. 2004 Jul 1;18(13):1553-64.

Cesari F, Rennekampff V, Vintersten K, Vuong LG, Seibler J, Bode J, Wiebel FF, Nordheim A. Elk-1 knock-out mice engineered by Flp recombinase-mediated cassette exchange.

Genesis. 2004 Feb;38(2):87-92.

Cesari F, Brecht S, Vintersten K, Vuong LG, Hofmann M, Klingel K, Schnorr JJ, Arsenian S, Schild H, Herdegen T, Wiebel FF, Nordheim A. Mice deficient for the ets transcription factor elk-1 show normal immune responses and mildly impaired neuronal gene activation.

Mol Cell Biol. 2004 Jan;24(1):294-305.

Testa G, Zhang Y, Vintersten K, Benes V, Pijnappel WW, Chambers I, Smith AJ, Smith AG, Stewart AF. Engineering the mouse genome with bacterial artificial chromosomes to create multipurpose alleles.

Nat Biotechnol. 2003 Apr;21(4):443-7.

Ambrosino C, Mace G, Galban S, Fritsch C, Vintersten K, Black E, Gorospe M, Nebreda AR. Negative feedback regulation of MKK6 mRNA stability by p38alpha mitogen-activated protein kinase.

Mol Cell Biol. 2003 Jan;23(1):370-81.

Wiebel FF, Rennekampff V, Vintersten K, Nordheim A. Generation of mice carrying conditional knockout alleles for the transcription factor SRF.

Genesis. 2002 Feb;32(2):124-6.

Adams RH, Porras A, Alonso G, Jones M, Vintersten K, Panelli S, Valladares A, Perez L, Klein R, Nebreda AR. Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development.

Mol Cell. 2000 Jul;6(1):109-16.