Summary
Overview
Work History
Education
Skills
Selectedpublications
Scholarshipsandawards
Languages
Awards
Timeline
Generic

Mitra Shourian

Montréal,Canada

Summary

Professional researcher with passion for advancing scientific knowledge. Proven track record in designing and executing research experiments, contributing to published studies. Known for strong team collaboration and adaptability, with key skills in data collection and statistical analysis.

Overview

18
18
years of professional experience

Work History

Research Associate

CHU Sainte-Justine Research Centre/University of Montreal
04.2024 - Current
  • Modified STAT5 signaling in the IL-2/IL-15 pathway using Short hairpin RNA (shRNA) techniques to investigate the impact on T-cell exhaustion and stemness characteristics in mouse CD8 and human CAR-T cells
  • Transferred genetically modified T cells into mouse models to assess the effects on T-cell exhaustion, and stem-like progenitor cell preservation in the context of chronic viral infections and cancer

Postdoctoral Research Scientist

CHU Sainte-Justine Research Centre/University of Montreal
09.2018 - 02.2024
  • Investigated the impact of IL-2/IL-15 signaling blockade on preventing T-cell exhaustion and preserving progenitor cells in chronic viral infections and cancer
  • Conducted in vitro assays to examine the impact on exhaustion markers in mouse CD8 and human CAR-T cells
  • Analyzed lymphoma patient samples for immune checkpoint expression on tumor infiltrating CD8 lymphocytes

Research Assistant

McGill University Health Center
01.2017 - 01.2018
  • Studied the role of innate lymphocyte cells in an animal model of asthma using advanced flow cytometry

Research Assistant

National Institute of Genetic Engineering and Biotechnology
01.2007 - 01.2009
  • Collaborated with multidisciplinary research personnel on various cell and molecular biology projects

Education

Ph.D. - Experimental Medicine

McGill University
Montréal, QC
01.2017

M.Sc. - Microbiology

Chamran University
Shahid Chamran University Of Ahvaz
01.2007

Skills

  • In Vitro Assays
  • In Vivo Experimentation
  • Flow Cytometry
  • Functional Assays
  • GraphPad Prism
  • FlowJo
  • ELISpot
  • ELISA
  • RT-qPCR
  • Nucleic acid isolation techniques
  • Scientific writing
  • Literature reviews
  • Data interpretation
  • Experimental design
  • Research planning
  • Critical thinking
  • Strong work ethic
  • MS office
  • Research presentation
  • Team collaboration
  • Knowledge sharing

Selectedpublications

  • Inhibition of IL2Rß-dependent STAT5 activity supports CD8 Tcell stemness and augments antitumor efficacy of cells for adoptive therapies, Shourian M
  • Ruisseaux C, Vallée A, Hachem N, Roméro H, Bourdin B, Beltra JC, Kwarteng E, Haddad E, Lavallée VP, Decaluwe H, Science Translational Medicine, 2024
  • Lack of stem-like exhausted T cells and increased inhibitory receptor expression distinguishes diffuse large B cell lymphomas from Hodgkin lymphoma, Vallée A
  • Shourian M
  • Decaluwe H, Journal of Immunology, 206, 2021, Supplement_1
  • Inhibition of JAK/STAT signaling sustain stem-like exhausted CD8+ T lymphocytes with enhanced antitumor effects, Shourian M, Bourdin B, Decaluwe H, Journal of Immunology, 206, 2021, Supplement_1
  • Evaluation of T-cell compartment by complex multiparameter flow cytometry reveals distinct patterns of T-cell exhaustion in DLBCL, FL and HL patients, Vallée A
  • Johnson N, Decaluwe H, Blood, 134, 2019, Supplement_1
  • Common gamma chain cytokines and CD8+ T cells in cancer, Shourian M
  • Beltra J.C
  • Bourdin B, Decaluwe H, Seminars in Immunology, 42, 2019
  • Resistance and tolerance to cryptococcal infection: an intricate balance that controls the development of disease, Shourian M, Qureshi ST., Frontiers in Immunology, 10, 2019
  • Contribution of IL-1RI signaling to protection against Cryptococcus neoformans 52D in a mouse model of infection, Shourian M, Ralph B, Angers I, Sheppard D, Qureshi ST., Frontiers in Immunology, 2018
  • The Cnes2 locus on mouse chromosome 17 regulates host defense against cryptococcal infection through pleiotropic effects on host immunity, Shourian M, Flaczyk A, Angers I, Mindt BC, Fritz JH, Qureshi ST., Infection and Immunity, 83, 2015

Scholarshipsandawards

  • Cole Foundation Fellowship, 09/01/19, 05/01/21
  • Travel Award, Meakins-Christie, McGill University, 01/01/14
  • Travel Award, Division of Experimental Medicine, McGill University, 01/01/13
  • Graduate Excellence Fellowship, McGill University, 01/01/12
  • Travel Award, Division of Experimental Medicine, McGill University, 01/01/12
  • Scholarship Award, Mouse Genetics Conference, Washington, DC, 01/01/11
  • Provost's Graduate Fellowship, McGill University, 01/01/10

Languages

English
Full Professional
Persian
Native or Bilingual

Awards


Cole Foundation Fellowship, 2019–2021

Travel Award, Meakins-Christie, McGill University, 2014

Travel Award, Division of Experimental Medicine, McGill University, 2013

Graduate Excellence Fellowship, McGill University, 2012

Travel Award, Division of Experimental Medicine, McGill University, 2012

Scholarship Award, Mouse Genetics Conference, Washington, DC, 2011

Provost's Graduate Fellowship, McGill University, 2010

Timeline

Research Associate

CHU Sainte-Justine Research Centre/University of Montreal
04.2024 - Current

Postdoctoral Research Scientist

CHU Sainte-Justine Research Centre/University of Montreal
09.2018 - 02.2024

Research Assistant

McGill University Health Center
01.2017 - 01.2018

Research Assistant

National Institute of Genetic Engineering and Biotechnology
01.2007 - 01.2009

Ph.D. - Experimental Medicine

McGill University

M.Sc. - Microbiology

Chamran University
Mitra Shourian