Summary
Overview
Work History
Education
Skills
Accomplishments
Affiliations
Timeline
Hi, I’m

Mona Abdel Hameed

Burnaby,British Columbia
Mona Abdel Hameed

Summary

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Biochemistry PHD graduate from the University of Manitoba (May 2015). Skilled in diverse protein purification techniques, optimizing yield and purity. Nine years of clinical biochemistry experience, proficient in molecular biology techniques, HPLC methods, and effective team collaboration. Proven track record in goal achievement, publication, and training. Dedicated and analytical, excelling in protein purification projects and medical laboratory testing. Skilled Researcher enthusiastic about supporting advancements in Biochemistry and molecular biology. Passionate about increasing knowledge to drive growth and needed improvements. Ready to apply knowledge and 15 years of experience in research. Detail-oriented Scientist well-versed in performing tests such as urinalysis, blood gasses and blood smears. Highly organized and diligent with systematic approach to handling specimens and conducting assessments. Ready to bring 10 years of related experience to challenging new role.

Overview

17
years of professional experience
2
Language

Work History

SignalChem Biotech Inc

Research Scientist
05.2022 - Current

Job overview

  • Began in IVD group, troubleshooting protein purification issues
  • Transitioned to protein purification team, pioneering safer, faster MBP extraction protocol, reducing time from 7 days to one
  • Currently in plant department, researching bacterial expression challenges using plant systems
  • Conducted diverse protein purifications
  • Developed innovative MBP extraction protocol without chloroform
  • Utilized plant expression systems for research
  • Incorporated noncanonical amino acids into proteins
  • Designed linkers for ADCs (Antibody-Drug Conjugates)
  • Developed pioneering protein incorporating non-canonical amino acids, opening new research avenues in cancer and Alzheimer's disease by enabling single phosphorylation of Tau and kinase proteins.

University of Manitoba

BIOCHEMICAL TECHNICIAN
10.2019 - 09.2021

Job overview

  • Collaborated with Dr
  • Ned Budisa, Canada Research Chair in Chemical Synthetic Biology, on pioneering bacterial evolution and genetic code engineering and established his biochemistry lab
  • Managed lab setup, experiment planning and execution, data analysis, protocol adherence, and research management
  • Conducted experiments on non-canonical amino acid incorporation into proteins
  • Trained over 7 students, including PhD, Master's, and Honors project students.

University of Manitoba

Post-Doctoral Fellow and Internship Chemist
04.2019 - 10.2019

Job overview

  • Project: Large-Scale Cultivation of Two Strains of KGS Bacteria
  • Objective: Explore biosynthetic potential of two KGS strains and assess metabolite bioactivity against crop-infecting fungi
  • Accomplishments: Optimized growing conditions to facilitate large-scale production of secondary metabolites
  • Conducted organic solvent extraction of KGS 3 fermentation media to isolate metabolites, maximizing yield and purity
  • Used TLC and HPLC for chromatographic analysis, identifying and quantifying metabolites
  • Developed conditions for ACI to fractionate crude extract, facilitating isolation of specific metabolites
  • Employed TLC, HPLC, and NMR spectroscopy for chemical characterization, identifying individual metabolites
  • Interpreted results to elucidate chemical composition and structural characteristics, revealing antifungal properties.

Cytophage Technologies Inc

Research Scientist
07.2018 - 03.2019

Job overview

  • At this company, focused on developing novel phage targeting multiple bacterial strains
  • Responsibilities: Led extraction, analysis, and large-scale production of bacteriophages from various sources
  • Applied molecular biology techniques like PCR, gel electrophoresis, DNA sequencing for genetic analysis
  • Used bioinformatics tools to annotate secondary metabolite gene clusters in phage genomes
  • Conducted protein expression studies and structural analysis to understand phage proteins
  • Conducted literature reviews on phage-bacteria interactions in different ecosystems.

University of Manitoba, Myera Nu, -Nomics Group Canada Inc
Agri

Post-Doctoral Fellow and Internship Chemist
01.2015 - 06.2018

Job overview

  • Project: Large-Scale Astaxanthin Production from Microalgae
  • Objective: Achieve large-scale astaxanthin production from Haematococcus pluvialis microalgae
  • Approach: Optimized growing conditions to maximize astaxanthin yield
  • Utilized advanced analytical techniques like HPLC and NMR for accurate quantification
  • Established and validated testing methodologies for astaxanthin production assessment
  • Developed protocol for carotenoid identification and separation using HPLC
  • Investigated astaxanthin characteristics under different conditions
  • Acquired expertise in cultivating microalgae, yeast, and fungi
  • Developed efficient extraction protocols for maximum astaxanthin yield
  • First to study and publish on astaxanthin stability in extracellular and intracellular forms, providing key guidelines for industry on extraction and storage.

University of Manitoba

Research Assistant
09.2007 - 12.2014

Job overview

  • Project: Polyketide Biosynthesis in Lichen Fungi
  • Objective: Investigate polyketide biosynthesis pathways in Cladonia uncialis
  • Approach: Utilized molecular biology and analytical chemistry techniques
  • Identified usnic acid gene cluster through genome sequencing
  • Discovered 56 putative biosynthetic gene clusters
  • Shed light on genetic basis of usnic acid biosynthesis.

Education

University of Manitoba

Doctor of Philosophy from Biochemistry
05

Ain Shams University

Master of Science from Biological and Natural sciences
05

Skills

  • Team building
  • Quantitative Research
  • Multitasking Abilities
  • Excellent Communication
  • Problem-solving aptitude
  • Laboratory Management
  • Time Management
  • Experiment Design
  • Scientific Writing
  • Quality Assurance Controls
  • Problem-solving abilities
  • Effective Multitasking
  • Grant Writing
  • Interpersonal Communication
  • Teamwork and Collaboration
  • Advanced Research Techniques
  • Research Planning
  • Data Analysis

Accomplishments

  • Developed a protocol for the extraction and purification of Myelin Basic Protein (MBP) from pig brain tissue, resolving prolonged extraction times and eliminating the use of harsh chemicals
  • Conducted pioneering research in integrating noncanonical amino acids into proteins, achieving the first production of single-phosphorylated proteins, and precise linker integration into ADCs
  • Pioneered study and publication of trace element levels in bladder cancer patients, opening new research avenues
  • Contributed to a two-year national medical screening initiative in Egypt, detecting viral hepatitis and liver cancer prevalence across 20 villages, leading to the diagnosis and treatment of thousands of patients
  • Co-authored published paper on the project
  • First to discover and publish groundbreaking research on gene clusters and metabolite production in lichens, including identification of usnic acid biosynthesis gene cluster, leading to a breakthrough in the field of natural product research
  • First to publish the complete genome sequence of Cladonia uncialis, marking a significant milestone in lichen genomics research
  • Published the first complete sequence of a gene potentially linked to 6-Hydroxymellein biosynthesis in Cladonia uncialis, inspiring new research and impacting the natural product field
  • Pioneered comprehensive study and publication on the stability of pure astaxanthin, both in vitro and in cells, catalyzing industry shifts in extraction, packaging, and storage processes.

Affiliations

Member, Canadian Society for Chemistry (CSC), 2010 to Present.

Timeline

Research Scientist

SignalChem Biotech Inc
05.2022 - Current

BIOCHEMICAL TECHNICIAN

University of Manitoba
10.2019 - 09.2021

Post-Doctoral Fellow and Internship Chemist

University of Manitoba
04.2019 - 10.2019

Research Scientist

Cytophage Technologies Inc
07.2018 - 03.2019

Post-Doctoral Fellow and Internship Chemist

University of Manitoba, Myera Nu, -Nomics Group Canada Inc
01.2015 - 06.2018

Research Assistant

University of Manitoba
09.2007 - 12.2014

University of Manitoba

Doctor of Philosophy from Biochemistry

Ain Shams University

Master of Science from Biological and Natural sciences
Mona Abdel Hameed