Mohammed Ali Alvi
Mississauga,ON
Summary
Clinical Research Scientist with a prolific publishing record consisting of more than 200 peer-reviewed academic publications in high-tier medical and surgical journals. Expert in gathering, cleaning, organizing and analyzing clinical data. Advanced understanding of statistical and machine learning techniques. Highly organized, motivated and diligent with significant background in surgical outcomes, healthcare analytics, spinal cord injury and MRI imaging.
Overview
7
7
years of professional experience
Work History
Data Science Consultant
Marlborough Capital
06.2023 - Current
- Extracted and assessed data from databases to drive improvement of product development and business strategies and processes.
- Discovered stories told by data to present information to scientists and business managers particularly pertaining to pharmaceutical research.
Data Scientist
Trust Certified
11.2022 - Current
- Utilized advanced querying, visualization and analytics tools to analyze and process complex data sets.
- Applied statistical and algebraic techniques to interpret key points from gathered data to create key performance indictors for physician performance.
- Extracted and assessed data from databases to drive improvement of product development and business strategies and processes for physician scoring.
- Provided guidance on establishing an infrastructure for capturing patient outcomes.
Post-Doctoral Fellow & Machine Learning Scientist
University Health Network - Toronto Western Hospit
04.2022 - Current
- Wrote research papers, reports, reviews, and summaries regarding surgical outcomes for patients undergoing surgery for traumatic and non-traumatic spinal cord injury.
- Completed analysis of data acquired from research and verified careful documentation of information.
- Collaborated with colleagues to gather research and publish findings.
- Wrote and published peer-reviewed articles concerning findings and highlighted possible applications for findings.
- Reviewed and analyzed historical and emerging literature to develop and practice new technologies.
- Developed unique research into Intraoperative Spinal Cord Injury (ISCI) and Use of Neuromonitoring to Detect and Prevent ISCI.
- Used Spinal Cord Toolbox (SCT) and Machine Vision for Measuring Multiparametric MRI findings for patients with non-traumatic spinal cord injury.
Healthcare Analytics Consultant
Voxanalytica
03.2022 - 04.2023
- Provided analytic consultancy on projects related to healthcare analytics, utilizing big data resources including claims data from Center for Medicare and Medicaid Services (CMS) and Other Claims Databases.
- Investigated the trends and disparities in utilization of treatment types for patients with lung cancer using advanced biostatistics
Lead Clinical Fellow and Analyst
NeuroPoint Alliance(NPA) Stereotactic Radiosurgery
07.2019 - 08.2021
The registry is aimed at providing national benchmarks for SRS treatments to provide clinicians and patients the data required to make informed treatment decisions. The registry objectives are to:1) Define national patterns of care in radiosurgery; 2) Improve healthcare outcomes and support informed decision-making; 3) Explore the potential to lower the cost of care delivery to patients. Registry information is used to help pinpoint more effective treatments for conditions affecting certain patient populations.
- Published our inaugural manuscript in collaboration with participating sites investigating factors associated with local failure of patients with intracranial metastasis in Journal of Neurosurgery (JNS).
- Investigated factors associated with intracranial progression (using RECIST criteria) among patients with intracranial metastasis, with a focus on role of radio-surgical parameters as covariates. Advanced predictive modeling and cut-off analyses were used to identify key drivers and thresholds of radiosurgical parameters.
- Investigated the quality of life of patient with intracranial metastasis after stereotactic radiosurgery (SRS) using predictive logistic regression modeling.
Lead Clinical Fellow
Quality Outcomes Database Tumor Registry
06.2018 - 07.2021
The QOD Tumor Registry follows patients receiving surgery for most primary and metastatic intracranial tumors. The registry collects patient demographics, presenting symptoms, comorbidities, histological diagnosis, operative characteristics including approach and use of surgical adjuncts, intraoperative and postoperative complications, hospital stay, 30-day readmission, recurrent surgery, progression and mortality. The registry also collects patient- reported outcomes (PROs) measuring cognition impairment, physical function, QALY and cognitive function after surgery.
- Led a team of 6 research fellows in developing the registry, including registry structure, data variables, collection plan and analyses efforts.
- Audited clinical data to verify feasibility of capture and confirm data validity
- Supervised communication to partners and donors
- Culminated the findings of pilot phase of the registry in a manuscript
Research Scientist
Mayo Clinic Rochester
08.2016 - 07.2021
- Created a practice dashboard for the Departments of Neurosurgery and Enterprise in collaboration with data visualization expert which automated real time updates regarding case volume, surgical outcomes, and practice patterns from the enterprise-wide neurosurgical cases registry. Incorporated a predictive model using real-time data to predict risk of readmission and surgical complication.
- Supervised up to 8 research fellows, and guided several medical and undergraduate students in ensuring adherence to IRB protocols, GMP and GCP guidelines, and executing several research projects.
- Using claims data to investigate drivers and regional patterns of cost and outcomes for patients undergoing spine surgery in collaboration with OPTUM Labs Data Warehouse (OLDW)
- Drafted and submitted grant proposals for acquiring funding for the CELLTOP trial, securing funding from Mayo Clinic Transform the Practice (TTP), Regenerative Medicine Minnesota (RMM), and Minnesota Office of Higher Education (MNOHE).
- Performed the analysis and drafted the manuscript for the pilot patient case report in our CELLTOP trial.
- Investigated the molecular and histopathological biomarkers of spinal high-grade gliomas in collaboration with and funded by the Department of Anatomic Pathology using Next Generation Sequencing (NGS).
- Investigated the effect of bed turnover rate on adverse events using a marginal structural model, funded by the Critical Care Research Committee.
- Continued to work on biomechanical analysis for Facet Joint Replacement (FJR) Device. Performed range of motion analysis with the prototype designs of our FJR device in collaboration with the Motion Analysis Laboratory.
- Investigated the molecular underpinning of black disc disease, using next generation mRNA sequencing and computational analysis, in collaboration with Department of Orthopedics, funded by the Mayo Clinic Center for Individualized Medicine.
- Conceptualized and launched a project to perform image segmentation for developing a deep-learning based predictive model to assess grade of lumbar spondylolisthesis using MRI images.
- Mentored up to 30 medical students, international resident fellows, and summer research students to execute research projects in the realm of surgical outcomes, healthcare economics and spinal cord injury.
- Responsible for concept development; acquisition, manipulation, and analyses of data; manuscript writing and journal submissions.
- Led the protocol development and launch of our pre-clinical study investigating the efficacy of umbilical cord stem cells for spinal cord injury in a rat contusion model, funded by the Sabes Foundation. Collaborated with IACUC and IRB on implementing animal safety protocols and best practices guidelines.
- Supported protocol specialist and a research fellow in the development of Investigational Device Exempt for CELLTOP. Worked with legal and IRB to implement compliance strategies and patient safety.
- Performed multiple systematic reviews and meta-analyses on outcomes of minimally invasive spine surgery.
- Performed background research on device market and feasibility of performing biomechanical analysis for a Facet Joint Replacement Device, in collaboration with the Mayo Clinic Department of Engineering, funded by the Mayo Clinic Innovation Accelerator Program.
Lead Clinical Fellow
Quality Outcomes Database (QOD) Spine Collaboratio
03.2017 - 05.2021
The Quality Outcomes Database (QOD) registries serve as a continuous national clinical registry for the most common neurosurgical procedures and provides individual surgeons, practice groups, hospitals, and healthcare systems with an immediate infrastructure for analyzing and reporting on the quality of their care.
- Coordinated data collection efforts across 12 clinical sites for the QOD Grade I Spondylolisthesis Study and across 14 clinical sites for the QPD Cervical Spondylotic Myelopathy (CSM) study.
- Analyzed data and prepared manuscripts, culminating in 22 publications in high-tier neurosurgery journals on various topics ranging from comparative efficacy research, comparing the outcomes of decompression alone and decompression and fusion for spondylolisthesis, to socioeconomic disparity research such as comparing the outcomes of patients on Medicaid with those on other insurances
Education
Ph.D. - Neuroscience
Institute of Medical Sciences, University of Toron
Toronto, ON12.2024
Master of Science - Clinical And Translational Sciences
Mayo Clinic Graduate School of Biomedical Sciences
Rochester, MN, USA08.2020
M.D. - Medicine
Dow University of Health Sciences - Sindh Medical
Karachi, Pakistan07.2016
Skills
- Methodology Implementation
- Data Research and Analysis
- System Modification
- Technique Optimization
- Statistical Reporting
- Quantitative Analysis
- Scripting Languages: PHP, Python, JavaScript
- Unsupervised Learning
- Medical Imaging
- Clustering Algorithms
- Data Processing
- Predictive Analytics
- Code Validation
- Clinical Research Trials
- Logistic Regression
- Statistical Methodology
Accomplishments
HONORS & AWARDS ACADEMIC CONTRIBUTIONS GRANTS / FELLOWSHIPS PATENTS
BOOK CHAPTERS
1. Kerezoudis P, Alvi MA, Goncalves S, Bydon M. “The Role of Clinical Registries in Health Care”. In: Quality and Safety in Neurosurgery: A Primer. Elsevier. 2018
2. Alvi MA, Kerezoudis P, Goncalves S, Maloney PR, Freedman BA, Nassr N, Berbari EF, Bydon M. “Epidural and Soft Tissue Infections”. In: Surgery of the Thoracic Spine: Principles and Techniques. Thieme. 2018
3. Alvi MA, Kurian DP, Kerezoudis P, Bydon M. “Lateral Lumbar Interbody Fusion”. In: Expert Techniques in Spine Surgery textbook. August 2019
4. Shepherd DL, Alvi MA Murphy M, Kerezoudis P, Corl F, Hitchon P, Nassr A, Bydon M. “The Cortical Bone Trajectory for Lumbar Spine Fusion”. In: Operative Techniques in Orthopaedics Special Spine surgery issue. December 2017 Submitted
5. Fogelson J, Kerezoudis P, Alvi MA, Goncalves S, Krauss W, Bydon M. “Management of Postoperative Complications in Spinal Surgery Patients withOsteoporosis”. In: Special Issue of Seminars in Spine Surgery on Osteoporosis and Spine surgery. March 2018. Submitted
6. Kerezoudis P, Rajjoub K, Alvi MA, Bydon M. “Cervical Laminoplasty”, In: Schmidek & Sweet’s Operative Neurosurgical Techniques Seventh Edition. Elsevier. Expected date of Publication: 2020.
7. Bydon M , Goyal A, Alvi MA; “Chapter 162- Minimally Invasive Lumbar Discectomy: Indications and techniques”, In: Schmidek & Sweet’s Operative Neurosurgical Techniques Seventh Edition. Elsevier. Expected date of Publication: 2020
8. Bydon M, Elminawy M, Alvi MA; “Conditions of Care and Episode Groups” In: Quality Spine Care: Healthcare Systems, Quality Reporting, and Risk Adjustment. Springer International. October 2018
9. Mohamad Bydon, MD; Mohammed Ali Alvi, MBBS, MS; Yagiz Yolcu, MD; RupaG. Juthani, MD; Ajit A. Krishnaney, MD; Chapter 174: Spine Registries; Steinmetz: Benzel's Spine Surgery 5/e; Expected Date of Publication: 2021
10. Ziya Gokaslan, MD; Mohamad Bydon, MD; Yagiz Yolcu, MD; Mohammed Ali Alvi, MBBS, MS; Chapter 160: Sacral Tumors: Regional Challenges; Steinmetz: Benzel's Spine Surgery 5/e; Expected Date of Publication: 2021
2017
Charles Kuntz Scholar Award for oral presentation titled: “Allograft Versus Autograft: A Comparison of Postoperative Morbidity in Spinal Fusions Using the ACS-NSQIP Registry”. Meghan E. Murphy, MD;
Brandon A. McCutcheon, MD; Jennifer Grauberger, MD; Daniel Shepherd, MD; Patrick R. Maloney, MD; Lorenzo Rinaldo, MD; Panagiotis Kerezoudis, MD; Jeremy L. Fogelson, MD; Ahmad Nassr, MD; Mohamad Bydon, MD. Joint Section
on Disorders of the Spine and Peripheral Nerves, Las Vegas, Nevada. Spine Summit 2017 - 33rd Annual Meeting
Best of Meeting Award for oral presentation titled: “The Effect of Epidural Steroid Injections on Bone Mineral Density and Vertebral Fracture Risk: A systematic review and critical appraisal of current literature”: Christy Hunt, Panagiotis Kerezoudis, Lorenzo Rinaldo, Mohammed Ali Alvi, Wenchun Qu, Timothy Maus, Mohamad Bydon ASRA’s 16th Annual Pain Medicine Meeting taking place November 16-18, 2017 at Disney’s Yacht & Beach Club Resorts in Florida
2018
AANS/CNS Section on Spine and Peripheral Nerves Presentation Abstract Award for oral presentation titled “Evaluating the role of Adjuvant Radiotherapy in Management of Sacral and Vertebral Chordoma: Results from a National Database”: Yagiz Yolcu, MD, Waseem Wahood, MD; Mohammed Ali Alvi, MBBS; Panagiotis Kerezoudis, MD; Scott H. Okuno, MD; Robert L. Foote, MD, Mohamad Bydon, MD. 34th Annual Meeting of the Section on Disorders of the Spine and Peripheral Nerves, 14-17th March, 2018
2019
J.A.N.E. Award. “Predictors of the Best Outcomes Following Minimally Invasive Surgery for Grade 1 Lumbar Spondylolisthesis.” Andrew Kai- Hong Chan, Erica F. Bisson, Mohamad Bydon, Steven D. Glassman, Kevin T. Foley, Eric A. Potts, Christopher I. Shaffrey, Mark E. Shaffrey, Domagoj Coric, John J. Knightly, Paul Park, Michael Y. Wang, Kai-Ming G. Fu, Jonathan Slotkin, Anthony L. Asher, Micheal S. Virk, Panagiotis Kerezoudis, Mohammed Ali Alvi, Jian Guan, Regis W. Haid, Praveen V. Mummaneni. 35th Annual Meeting of the Section on Disorders of the Spine and Peripheral Nerves, 14-17th March, 2019.
Kuntz Scholar Award for Top Abstracts. “Assessing the Differences in Characteristics of Patients Lost to Follow Up at 2 Years: Results from the Multi-site Quality Outcomes Database (QOD) Study of Impact of Fusion on Outcomes of Grade 1 Spondylolisthesis.” Praveen V. Mummaneni, Mohamad Bydon, John J. Knightly, Mohammed Ali Alvi, Andrew Kai- Hong Chan, Panagiotis Kerezoudis, Jian Guan, Michael V. Biase, Andrea Strauss, Steven D. Glassman, Kevin T. Foley,
Jonathan Slotkin, Eric A. Potts, Christopher I. Shaffrey, Mark E. Shaffrey, Regis W. Haid Jr., Kai- Ming G. Fu, Michael Y. Wang, Paul Park, Anthony L. Asher, Erica F.
Bisson. 35th Annual Meeting of the Section on Disorders of the Spine and Peripheral Nerves, 14-17th March, 2019.
Best Oral Presentation – Peripheral Nerve/ Basic Science/ General Spine Session 5. “Spinal Cord High-grade Infiltrating Gliomas in Adults: Clinico- pathological and Molecular Evaluation” Panagiotis Kerezoudis, Mohammed Ali Alvi, Cristiane Ida, Michael Paolini, Jenna Meyer, Emily G. Barr Fritcher, Sandy Goncalves, Fredric B. Meyer, Mohamad Bydon, Aditya Raghunathan. 35th Annual Meeting of the Section on Disorders of the Spine and Peripheral Nerves, 14-17th March, 2019.
Clinical Science Award. “Impact of Opioid Prescribing Guidelines on Postoperative Narcotic Prescriptions Following Elective Spine Surgery” William Krauss, MD; Elizabeth Habermann, Ph.D, MPH; Anshit Goyal, MBBS; Mohammed Ali Alvi, MBBS; Daniel Ubl; Daniel Whipple, MS; Amy E. Glasgow, MHA; Halena M. Gazelka, MD; Matthey T. Neal, MD; Bernard Bendok, MD; Selby Chen, MD; Alfredo Quinones-Hinojosa, MD; Mohamad Bydon, MD. 71st Southern Neurosurgical Society Annual Meeting, February 26th – February 29th , 2020.
2020
Charles Kuntz Scholar Award. “Impact of Opioid Prescribing Guidelines on Postoperative Narcotic Prescriptions Following Elective Spine Surgery” William Krauss, MD; Elizabeth Habermann, Ph.D, MPH; Anshit Goyal, MBBS; Mohammed Ali Alvi, MBBS; Daniel Ubl; Daniel Whipple, MS; Amy E. Glasgow, MHA; Halena M. Gazelka, MD; Matthew T. Neal, MD; Bernard Bendok, MD; Selby Chen, MD; Alfredo Quinones- Hinojosa, MD; Mohamad Bydon, MD. Spine
Summit 2020 - 36th Annual Meeting of the Section on Disorders of the Spine and Peripheral Nerves, March 05-08, 2020
COVID Social Isolation Challenge for April, 2020: 2nd Prize with 23.5 points, with 22 manuscript submissions.
1. Brown D, Kerezoudis P, Alvi MA, Bydon M. Minimally Invasive Cervical Foraminotomy for Radiculopathy. NEXUS: CNS Online Educational site. 2017.
2. Snyder K, Kerezoudis P, Alvi MA, Bydon M. Lateral Lumbar Interbody Fusion for Adjacent Segment Disease. NEXUS: CNS Online Educational site. 2017.
3. Gates M, Yoon J, Alvi MA, Kerezoudis P, Bydon M. 2-level Arthroplasty for Cervical Spondylosis. NEXUS: CNS Online Educational Site, 2017 MIS Reduction.
4. Murphy M, Alvi MA, Kerezoudis P, Bydon M. Transforaminal Lumbar Interbody Fusion for high-grade spondylolisthesis. NEXUS: CNS Online Educational Site, 2017.
Bydon (PI) 2016 - 2018
“Investigating the Molecular Underpinnings of Black Disk Disease”.
Funded by: the Center of Individualized Medicine – Mayo Clinic, Rochester, Mn Role: Co-investigator
Bydon (PI) 2016 - Ongoing
“Facet Joint Replacement Device. Collaborative effort with the Division of Engineering”. Funded by: Mayo Clinic Innovation Accelerator Program
Role: Co-investigator
Qu (PI) 2016 - Ongoing
“A Phase I Study Evaluating the Safety and Feasibility of Adipose-Derived Mesenchymal Stem Cells for Treatment of Painful Degenerative Disc Disease”.
Funded by Mayo Clinic Transform The Practice grant – Mayo Clinic, Rochester, Mn. Role: Co-investigator
Bydon (PI) 2017 - 2020
“CELLTOP: Phase I/II Clinical Trial of Autologous Adipose Derived Mesenchymal Stem Cells in the Treatment of Paralysis due to Traumatic Spinal Cord Injury” (IND #17387).
Funded by Regenerative Medicine Minnesota. Role: Co-investigator
Bydon (PI) 2017 - 2020
“Safety and Feasibility Study of Umbilical Cord Derived Stem Cell Injections in Rat Models of Spinal Contusion” Funded by: Sabes Foundation; in collaboration with Animal Cell Therapies, Inc.
Role: Co-investigator
Bydon (PI) 2017 - 2020
“Uncovering the Molecular and Histological Biomarkers of Spinal High-Grade Gliomas: A Clinico-Pathological Investigation”
Funded by: Anatomic Pathology Department, Mayo Clinic Rochester, Mn Role: Co-investigator
Bydon (PI) 2017 - 2018
“Association Between Bed Turnover Rate and Adverse Events”
Funded by: Mayo Clinic - Critical Care Research Committee, Mayo Clinic Rochester, Mn Role: Co-investigator
Bydon (PI) 2019 - 2022
“Multi dose safety and feasibility study of Autologous Culture Expanded Adipose Derived Mesenchymal Stem Cells (AD-MSCs) in the Treatment of Traumatic Spinal Cord Injury”
Funded by: Minnesota Office of Higher Education, MN Role: Co-investigator
Bydon (PI) 2019 - 2021
“Using Practice Based Evidence to Facilitate Neurosurgical Quality Improvement” Funded by: The Kern Center for the Science of Health Care, Mayo Clinic, Rochester, Mn Role: Co-investigator
Bydon (PI) 2020 - 2021
“Deep Learning to Detect Spine Pathology from Magnetic Resonance Imaging and X-ray” Funded by: The Kern Center for the Science of Health Care, Mayo Clinic, Rochester, Mn Role: Co-investigator
Kurian (PI) 2019 - 2020
“Are All Outpatient Surgery the Same? Evaluating the Differences in Outcomes of Patients Undergoing Routine Spine Surgery at Hospital Outpatient vs. Free-Standing Ambulatory Surgical Centers”
Funded by: Department of Neurologic Surgery, Mayo Clinic – Uihlein Professorship Research Grant Role: Co-investigator
Bhandarkar (PI)2020 - 2021
“Development and Validation of a Machine Learning Model for Predicting Extended Length of Stay after Acute Subdural Hematoma Evacuation”
Funded by: Department of Neurologic Surgery, Mayo Clinic– Uihlein Professorship Research Grant Role: Co-investigator
Mohamad Bydon M.D., Chunfeng Zhao M.D., Hugo Giambini Ph.D., Brandon A. McCutcheon M.D., Panagiotis Kerezoudis M.D., Timothy L. Rossman, Allen K. Rech, Joel L. Kuhlmann, Mohammed A. Alvi M.B.B.S., Daniel (Clay) J. Mangiameli, Robert A. Highet; “Facet Joint Replacement Device”; 15/698,357;
Mohamad Bydon M.D., Chunfeng Zhao M.D., Hugo Giambini Ph.D., Brandon A. McCutcheon M.D., Panagiotis Kerezoudis M.D., Timothy L. Rossman, Allen K. Rech, Joel L. Kuhlmann, Mohammed A. Alvi M.B.B.S., Daniel (Clay) J. Mangiameli, Robert A. Highet; “Facet Joint Replacement Device”; 62/575,196;
Citations: 2415
h-index: 27
i10 index: 69
Family, Cricket, Football, Satire,
The best part of my day is the part spent with my family.
Timeline
Data Science Consultant
Marlborough Capital
06.2023 - Current
Data Scientist
Trust Certified
11.2022 - Current
Post-Doctoral Fellow & Machine Learning Scientist
University Health Network - Toronto Western Hospit
04.2022 - Current
Healthcare Analytics Consultant
Voxanalytica
03.2022 - 04.2023
Lead Clinical Fellow and Analyst
NeuroPoint Alliance(NPA) Stereotactic Radiosurgery
07.2019 - 08.2021
Lead Clinical Fellow
Quality Outcomes Database Tumor Registry
06.2018 - 07.2021
Lead Clinical Fellow
Quality Outcomes Database (QOD) Spine Collaboratio
03.2017 - 05.2021
Research Scientist
Mayo Clinic Rochester
08.2016 - 07.2021
Ph.D. - Neuroscience
Institute of Medical Sciences, University of Toron
Master of Science - Clinical And Translational Sciences
Mayo Clinic Graduate School of Biomedical Sciences
M.D. - Medicine
Dow University of Health Sciences - Sindh Medical
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