Summary
Overview
Work History
Education
Skills
Publications
Timeline
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MALINI BHADRA

MALINI BHADRA

Singapore

Summary

A seasoned researcher with over 10 years of experience in designing and executing projects within the molecular biology field. With a PhD in Biological Sciences from NTU, my expertise extends to 3 years of immersive training in cutting-edge molecular biology techniques, complemented by a deep understanding of the pharmaceutical industry, particularly in biopharmaceutical manufacturing and regulatory affairs. As a fluent and relatable communicator, I have demonstrated a track record of producing multiple publications and delivering compelling presentations. My professional passion lies in fostering growth within the biotechnology and healthcare industry. I am enthusiastic about leveraging my extensive research background, scientific acumen, critical thinking, problem-solving prowess, and exceptional interpersonal skills to make substantial contributions to the continuous advancement of any organization.

Overview

13
13
years of professional experience

Work History

Global Services and Support Trainer

Thermo Fisher Scientific
06.2021 - Current
  • Conducting comprehensive trainings in molecular biology techniques tailored for the Asia Pacific Region
  • Coordinating with internal and external stakeholders globally for continious improvement of Global Applications Training Program
  • Ensuring strict adherence to ISO standards for rigorous training process compliance and certifications
  • Designing and developing courses to integrate into the Learning Management System, ensuring global accessibility and engagement
  • Strategically procuring cost-effective equipments, reagents, and consumables to optimize training effectiveness
  • Exercising adept management skills to oversee the applications lab, meticulously implementing, and maintaining the 5S process for operational excellence
  • Leading and actively participating in diverse projects, including the relocation of the training center, developing global applications learning website and the migration of the Learning Management System.

Post-Doctoral Fellow - Dr William Mair’s lab

Harvard T.H. Chan School of Public Health
05.2019 - 06.2020
  • Studied RNA splicing targets of the splicing factor, SFA-1 and SF3A2 in C.elegans and in mammalian cell line with the goal of finding targets affecting longevity
  • Performed lifespan assays for splicing targets of these splicing factors in C.elegans
  • Design and execute experiments independently and in a team
  • Research data analysis and troubleshooting
  • Published a review article in a scientific journal.

Post-Doctoral Fellow - Dr Xavier Roca’s lab

Nanyang Technological University, Singapore
03.2017 - 04.2019
  • Studied the effects of SNPs on splicing, using CRISPR knockout, plasmid construction and mutagenesis
  • Analysed splicing levels for mutant plasmids by real time PCR and measured cell-death by trypan blue assay and MTS assay
  • Plan and execute experiments involving establishment of new CRISPR genome editing technique
  • Research data analysis and troubleshooting and periodically present data and research findings in seminars
  • Mentor, coach, and manage undergraduate students and fellow researchers
  • Manage laboratory’s procurement, equipment, and record keeping of all research data.

PhD - Dr Xavier Roca’s lab

Nanyang Technological University, Singapore
08.2012 - 02.2017
  • Use site-directed mutagenesis to introduce deletions and mutations in minigene plasmids
  • Conduct real time PCR to analyze splicing changes of mutant plasmids to determine splicing elements
  • Use knockdown/overexpression assays and RNA pull-down assay to find splicing factors regulating splicing
  • Design, execute, troubleshoot, and complete research project leading to a doctoral thesis Collaborate and co-author research articles and presentations
  • Involved in teaching course modules, tutorials and handle practical laboratory classes for undergraduate students and mentor undergraduates for their final year projects
  • In charge of lab safety management.

Dossier conformance data specialist - Regulatory Affairs

Pfizer Singapore (Tuas)
02.2011 - 02.2012
  • Interacted with Country affiliates to obtain product dossiers (chemistry manufacturing and control documents) registered with their local health authority
  • Ensured compliance of registration dossiers to ICH standards and loaded them into global document management system for greater visibility to all regulatory personnel worldwide.

Education

Doctor of Philosophy in Biological Sciences -

Nanyang Technological University, Singapore
12.2016

Bachelor of Science (Hons) in Pharmaceutical Management -

Management Development Institute of Singapore (Univ of Bradford, UK), Singapore
12.2009

Skills

  • Conducting and organizing scientific trainings and developing training courses
  • Development, optimization, troubleshooting and implementation of new protocols leading to consistent yield of experimental results
  • Critical thinking in analysing experimental data sets and drawing conclusions
  • Fluent communicator and well versed in presentation, independent and self-driven with ability to work well in a team setting
  • Structured and organized, ensuring smooth laboratory management including Laboratory’s procurement, equipment and record keeping of lab protocols and experiments
  • Supervising and mentoring undergraduate students and fellow colleagues
  • Competent in Microsoft PowerPoint, Word, and Excel, Google Docs
  • Biorender
  • PCR and Real time PCR (qRT-PCR) for gene expression analysis
  • Microarray technique
  • Cloning for plasmid construction
  • DNA and RNA extraction
  • Routine mammalian cell culture and maintenance
  • CRISPR genome editing, siRNA-mediated gene silencing
  • RNA-pull down assay and Western blotting for protein expression analysis
  • MTS Assay to determine apoptotic cell death

Publications

  • Liu J., Bhadra M., Sinnakannu JR., Yue WL., Rigo F., Ong ST., Roca X. 2017. Overcoming imatinib resistance conferred by the BIM deletion polymorphism in chronic myeloid leukemias with splice-switching antisense oligonucleotides. Oncotarget.
  • Ong AAL., Tan J, Bhadra M., Dezanet C., Patil KM., Chong MS., Kierzek R., Decout JL., Roca X., Chen G. 2019. RNA Secondary Structure-Based Design of Antisense Peptide Nucleic Acids for Modulating Disease-Associated Aberrant Tau Pre-mRNA Alternative Splicing. Molecules.
  • Bhadra M., Howell P., Dutta S., Heintz C., and Mair WB. 2019. Alternative splicing in aging and longevity. Human Genetics.

Timeline

Global Services and Support Trainer

Thermo Fisher Scientific
06.2021 - Current

Post-Doctoral Fellow - Dr William Mair’s lab

Harvard T.H. Chan School of Public Health
05.2019 - 06.2020

Post-Doctoral Fellow - Dr Xavier Roca’s lab

Nanyang Technological University, Singapore
03.2017 - 04.2019

PhD - Dr Xavier Roca’s lab

Nanyang Technological University, Singapore
08.2012 - 02.2017

Dossier conformance data specialist - Regulatory Affairs

Pfizer Singapore (Tuas)
02.2011 - 02.2012

Doctor of Philosophy in Biological Sciences -

Nanyang Technological University, Singapore

Bachelor of Science (Hons) in Pharmaceutical Management -

Management Development Institute of Singapore (Univ of Bradford, UK), Singapore

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