JESSICA PAREDES
Tracy,CA
Summary
Meticulous Research Associate with professional hands-on expertise in cell culture, tumor sample handling, and assay development. Experienced in advancing preclinical research through the development and optimization of experimental protocols. Highly motivated and goal driven, with strong determination to learn. Seeking to contribute expertise in drug discovery to a dynamic biopharma team.
Overview
5
5
years of professional experience
Work History
Research Associate II
Frontier Medicines
08.2022 - 02.2025
- Successfully delivered a drug candidate for the clinic, advancing it through key stages of preclinical development and optimizing its efficacy for targeted therapeutic applications.
- Performed SAR (Structure-Activity Relationship) studies, optimizing lead compounds for improved potency, selectivity, and pharmacokinetic properties.
- Performed routine cell culture maintenance for various cell lines, ensuring optimal growth conditions, passaging, and contamination-free environments.
- Developed and optimized cell viability assays, apoptosis, and proliferation assays to assess the efficacy of lead compounds.
- Assisted in the processing and handling of tumor samples for biomarker analysis, including performing molecular analysis on tumor tissues to assess drug efficacy.
- Worked closely with CRO's to facilitate the transfer of in-house assays.
- Analyzed and interpreted complex data sets, generating visual representations using Prism, Excel, and PowerPoint
Research Associate
R2M Pharma
08.2021 - 06.2022
- Evaluated compounds in various assay formats such as fluorescent binding, kinase, and cAMP-Gi
- Converted 96 and 384 well manual assays to automated formats using the Agilent Bravo Liquid Handling System and Multidrop
- Programmed the Bravo in processes that include serial dilutions and plate dispenses
- Imported and analyzed compound IC50 values in CDD Vault database
- Performed cell culture, including inoculation of cells into flasks and maintenance of media in sterile conditions
- Followed standard operating procedures (SOPs) when performing tasks such as harvesting cells from tissue cultures
- Assisted scientists during research projects by preparing reagents and solutions required for specific assays
- Measured assay data readings using 2 detections readers, BMG PHERstar and BioTek Synergy Neo2
Clinical Lab Accessioner Lead
Color Health
01.2021 - 08.2021
- Assisted in reviewing and updating the lab's SOPs to reflect current protocols
- Lead a team of twelve accessioners by communicating their goals and helping them understand their roles in achieving them
- Conducted interviews with potential members of the accessioning team and helped with the onboarding procedure
- Trained and supervised incoming laboratory and testing personnel in standard practices in sample processing
- Reported all potential problems with PHI and/or HIPAA compliance immediately to supervisor
Clinical Lab Accessioner
Color Health
08.2020 - 01.2021
- Received and accessioned patient samples in a highly automated, high throughput CLIA-certified COVID-19 testing BSL-2 laboratory
- Operated automated machinery including Thermomixers, Biotek Synergy NEO2 and STAR/STARlet liquid handlers
- Developed equipment troubleshooting skills to address technical issues
- Used LIMS, JIRA, and Slack to collaborate with the engineering and support teams to find solutions for cases of missing patient information, data inconsistencies, and other sample processing-related problems
- Performed routine laboratory maintenance, such as equipment maintenance and standard lab cleanliness to ensure a safe laboratory environment
Education
B.S. - Biology with an emphasis in Human Biology, Psychology
University of California
07.2020
Skills
- Culturing and maintaining mammalian cell lines: adherent and suspension
- Transfection (viral transduction)
- Cell-based assays: cell viability, apoptosis (annexin v, caspase 3/7), cell cycle, MSD ELISA
- Handling and processing of tumor samples
- Western Blotting - Simple Western
- Biochemicay assay: AlphaLISA
- Assay Development
- Data analysis and visualization: GraphPad Prism, Dotmatics, Excel, PowerPoint
- Data management, laboratory documentation, experimental design
- CRO management
- SOP (Standard Operating Procedure) development and documentation
- Laboratory safety protocols, biosafety standards
Timeline
Research Associate II
Frontier Medicines
08.2022 - 02.2025
Research Associate
R2M Pharma
08.2021 - 06.2022
Clinical Lab Accessioner Lead
Color Health
01.2021 - 08.2021
Clinical Lab Accessioner
Color Health
08.2020 - 01.2021
B.S. - Biology with an emphasis in Human Biology, Psychology
University of California
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