Hai-Tuong Le

Skilled Researcher enthusiastic about supporting advancements in biochemistry. Passionate about increasing knowledge to drive growth and needed improvements. Ready to apply knowledge and 5+ years of experience in research and expertise in microbiology, biochemistry. Skilled multitasker with excellent communication and problem-solving skills. Proven history of maintaining equipment and lab areas in alignment with regulatory guidelines. Dedicated Life Scientist with experience in laboratory research. Expertise in data analysis and background in biochemistry and genetics. Proficient in advanced laboratory equipment use and techniques.

• 1-Malki A, Le HT (first co-authors), Milles S, Kern R, Caldas T, Abdallah J, Richarme G. "Solubilization of protein aggregates by the acid stress chaperones HdeA and HdeB". J Biol Chem. 2008 May 16;283(20):13679-87
• 2- Kthiri F, Le HT, Tagourti J, Kern R, Malki A, Caldas T, Abdallah J, Landoulsi A, Richarme G. "The thioredoxin homolog YbbN functions as a chaperone rather than as an oxidoreductase". Biochem Biophys Res Commun. 2008 Oct 3;374(4):668-72
• 3- Le HT, Chaffotte A.F, Thomas E.D, Vinh J, Friguet B, Mary J. "Impact of hydrogen peroxide on the activity, structure and conformational stability of the oxidized protein repair enzyme methionine sulfoxide reductase A". J Mol Biol. 2009 Oct 16;393(1):58-66
• 4- Kthiri F, Le HT (first co-author), Gautier V, Caldas T, Malki A, Richarme G. "Protein aggregation in a mutant deficient in the bacterial homolog YajL of the Parkinsonism associated protein DJ-1". J Biol Chem. 2010 Apr 2;285(14):10328-36
• 5- Kthiri F, Gautier V, Le HT, Prère MF, Fayet O, Malki A, Landoulsi A, Richarme G. "Translational defects in a mutant deficient in YajL, the bacterial homolog of the parkinsonism-associated protein DJ-1". J Bacteriol. 2010 Dec;192(23):6302-6
• 6- Le HT, Gautier V, Kthiri F, Kohiyama M, Katayama T, Richarme G. "DNA replication defects in a mutant deficient int the thioredoxin homolog YbbN". Biochem Biophys Res Commun. 2011 Feb 4;405(1):52-7
• 7- Le HT, Gautier V, Kthiri F, Malki A, Messaoudi N, Mihoub M, Landoulsi A, An YJ, Cha SS, Richarme G. "YajL, the prokaryotic homolog of the Parkinsonism associated protein DJ-1 functions as a covalent chaperone for the thiol proteome". J Biol Chem. 2012 Feb 17;287(8):5861-70
• 8- Gautier V, Le HT, Malki A, Messaoudi N, Caldas T, Kthiri F, Landoulsi A, Richarme G. "YajL, the Prokaryotic Homolog of the Parkinsonism-Associated Protein DJ-1, Protects Cells against Protein Sulfenylation". J Mol Biol. 2012 Aug 24;421(4-5):662-70
• 9- Mills A, Le HT, Coulton JW, Duong F. "FhuA interactions in a detergent-free nanodisc environment". Biochim Biophys Acta. 2014 Jan;1838(1 Pt B):364-71
• 10- Mills A, Le HT, Duong F. "TonB-dependent ligand trapping in the BtuB transporter". Biochim Biophys Acta. 2016 Oct 5;1858(12):3105-3112