Fariborz Soheili
Ottawa,ON
Summary
Extensive experience in translational research focusing on understanding genetic and molecular mechanisms behind arterial calcification, congenital heart diseases, and cancer genetics. Proficient in utilizing transgenic mouse models, gene expression profiling, and advanced molecular techniques to uncover valuable insights. Successful track record of publishing peer-reviewed research and presenting at international conferences. Skilled educator in genetics and biochemistry, actively contributing to genetic counseling and hereditary disease screening programs. Ultimate goal is to bridge the gap between basic research and clinical applications to enhance patient outcomes.
Overview
11
11
years of professional experience
Work History
Research Scientist
Cellular and Molecular Research Center, KUMS,
09.2007 - 09.2011
Faculty Member (Researcher &Lecturer)
Medical University of Kurdistan
09.2007 - 09.2011
Faculty Member (Researcher &Lecturer)
Faculty of Science Chabahar University
09.2011 - 08.2018
Education
Ph.D. - Biochemistry specialized in Human and Molecular Genetics
04-2025
Thesis: Genetic variants mechanisms contributing to arterial calcification
- Supervisor: Dr. Erin Mulvihill
M.Sc. - Genetics
09-2007
Thesis: Pathogenic Mutations analysis of P53 gene in patients affected with hepatocellular carcinoma
- Supervisor: Dr. Hamid Galadari
B.Sc. - Biology
01.2005
Skills
- Cardiovascular Research
- Cancer Research
- Clinical biochemistry expertise
- Stem cell differentiation studies
- Molecular Biology Techniques
- Cell Biology Techniques
- Bioinformatics Analysis
- Clinical Data Analysis
- Animal Models,
- Genetic Engraining
- Scientific Communication
- Instructional expertise
- Arterial Calcification Research
- Grant proposal drafting
Skill language
Kurdish (Fluent)
Persian (Fluent)
English (Fluent)
French (Basic)
Accomplishments
2023 Nicole Bégin-Heick Schol
2023 Fac MED Schol Grad Research
2023 Ontario Student Assistance Program (OSAP)
2023 BMO Financial Grad Bursaries
2022 Endowed Fellowship and Scholarship, UOHI
2022 Langevin-Desrochers Doc Burs
2022 Int'l Doctoral Scholarship
2021 Admissions Scholarship-Doctorate
2020 Int'l Doctoral Scholarship
2019 Langevin-Desrochers Doc Burs
2019 Int'l Doctoral Scholarship
2018 Int'l Doctoral Scholarship
2017 Active Researcher of Sciences Faculty Award,Department of Biology, Chabahar, Iran
2016 Active Researcher of Sciences Faculty Award Department of Biology, Chabahar, Iran
2015 Top university researcher Award Department of Biology, Chabahar, Iran
2010 The Youngest Faculty Achievement Award: Pioneering Generation of Transgenic Mice in Iran
2007 Graduate as Rank 1 University
2005 Rank 9 cell and molecular biology Olympiad
RESEARCH EXPERIENCE/PROJECTS
- Genetic Variants Mechanism of Coronary Arterial Calcification
- Bisphosphonate Therapy effect on arterial calcification in MgpKO mice
- Genotype-Phenotype Correlation in Isolated Congenital Heart Diseases: Mutation Analysis of GATA4, NKX2.5, and TBX5
- HPV Clinical Relevance in Esophageal Squamous Cell Carcinoma
- Generation of the First Transgenic Mouse with Green Fluorescent Protein Expression in Iran
- Efficiency of Stem Cell Isolated from Murine Bone Marrow and Compact Bone and transdiffertion to cardiomyocte
- Cytotoxic Effects of Algae Extract on Cancer DNA
- VEGFR Gene Expression Inhibition by Chitosan-siRNA Nanoparticles in Cancer Stem Cells
- Isolation, Cultivation, and Transfection of Human Keratinocytes
- Incidence of Nosocomial P. aeruginosa Infections in Kurdistan Burn Patients
- Metallo-β–Lactamase Producers Survey in Pseudomonas aeruginosa Isolated from Kurdistan Burn Center
SELECTED PEER-REVIEWED JOURNAL ARTICLES
(https://scholar.google.com/citations?user=ii9y2sMAAAAJ)
1. Asrin Rashidi, Ernst-Martin Füchtbauer, Zakaria Vahabzadeh, Farzad Soleimani, Karim Rahimi, Bahram Nikkhoo, Shohreh Fakhari, Mohammad Bagher Khadem Erfan, Asaad Azarnezhad, Arash Pooladi, Soheili Fariborz, Fardin Fathi, CRISPR/Cas9-mediated knockout of DYRK1B in triple-negative breast cancer cells: implications for cell proliferation, apoptosis, and therapeutic sensitivity, Biochemical Engineering Journal, 2025, 213
2. Fariborz Sheili, Niloufar Heydarikhorneh, Ragnar O. Vilmundarson, Alexandre Stewart. 9p21.3 genetic variants increase coronary calcification by suppressing smooth muscle statherin expression. Nature communication 2025
Abstract: Circulation, Volume 150, https://doi.org/10.1161/circ.150.suppl_1.4141501
3. Fariborz Soheili, Niloufar Heydarikhorneh, Benjamin Rotstein, and Alexandre Stewart. Alendronate improves dental malocclusion but worsens arterial calcification in Mgp-null mice by modulating macrophage hydroxyapatite uptake to lysosomes. PLOS One. PONE-D-25-52970 March 2025 revised submitted
Abstract: Circulation, Volume 150, https://doi.org/10.1161/circ.150.suppl_1.4141690
4. Fariborz Soheili, Niloufar Heydarikhorneh, Zahra Jalili, Ragnar Vilmundarson, Samira Foladi, Fardin Fathi, Asrin Rashidi, Sona Zare, Alexandre Stewart. Structural and Clinical Analysis of Novel Tbx5 Mutations in Kurdish Patients with Isolated Cardiac Defects JMCC17074 April 2025
5. Vilmundarson Ragnar, Duong An, Fariborz Soheili, Chen Hsiao-Huei, Stewart Alexandre. IRF2BP2 3′ UTR Polymorphism Increases Coronary Artery Calcification in Men. Frontiers in Cardiovascular Medicine. 2021:1423.
6. Vilmundarson RO, Heydarikhorneh N, Duong A, Ho T, Keyhanian K,Fariborz Soheili , Chen HH, Stewart AF. Savior Siblings Might Rescue Fetal Lethality But Not Adult Lymphoma in Irf2bp2- Null Mice. Frontiers in Immunology. 2022 Jul 4; 13:868053.
7. Fariborz Soheili, Zahra Jalili, Mahtab Rahbar, Zahed Khatooni, Amir Mashayekhi, Hossein Jafari. Novel Mutation of GATA4 gene in Kurdish population of Iran with Non-syndromic congenital heart septals defects. Congenit Heart Dis. 2018 Mar;13(2):295-304.
8. Fariborz Soheili, Bahram Nikkho, Mazaher Khodabandehloo. Determination of the Physical Status (Episomal/Integral) of HPV by qPCR in Esophageal Squamous Cell Carcinoma. International Journal of Enteric Pathogens. 2017 February; 5(1):1-4.
9. Fariborz Soheili, Niloufar Heydarikhormeh, Mahtab Rahbar, Bahram Nikkho, Omid Fotouhi, Abdolrahim Afkhamzadeh, Hossein Jafari & Vahid Bagheri., Human papillomavirus and its clinical relevance in oesophageal squamous cell carcinoma in a Kurdish population in the west of Iran. INFECTIOUS DISEASES, 2016 VOL. 48, NO. 4, 270–273.
10. Fariborz Soheili, Parichehr Darabi, Fatemeh Dahmardeh, Nilofar Heidary, Zahra Jalili, Samira Fooladi,Mohammad Saeid Hakhamanesh, and Maseoud Heidarizadeh., Nkx2-5 Mutations in Patients with Nonsyndromic Congenital Heart Disease. Zahedan Journal of Research in Medical Sciences. 2016 January; 18(1): e5873.
11. Fariborz Soheili, Galehdari Hamid*, Foroughmand Ali mohamad, Masjedizadeh Abdolrahim., Lack of Mutation in the Hot Spot Region of the Human P53 Gene in a Number of Iranian Hepatocellular Carcinoma Patients. Iranian Journal of Pathology (2010)5 (3), 116 -120.
SELECTED PRESENTATIONS
1. Soheili F, Niloufar Heydarikhorneh, Alexandre F. R. Stewart. Abstract 4141690: Bisphosphonate therapy improves bone deficits but worsens arterial calcification in Mgp-null mice. American Heart Association's 2024 Scientific Sessions and the American Heart
2. Soheili F, Niloufar Heydarikhorneh, Ragnar O. Vilmundarson, Alexandre F. R. Stewart. Mechanism whereby the chromosome 9p21.3 locus affects arterial calcification. American Heart Association's 2024 Scientific Sessions and the American Heart
3. Soheili F, Heydarikhorneh N, Chen H, Stewart A., Bisphosphonate therapy worsens arterial calcification at MgpKO mice. Toronto Ottawa Heart Summit, June 2024
4. Soheili F, Heydarikhorneh N, Chen H, Stewart A., how to 9p21.3 contribute to coronary arterial calcification. Toronto Ottawa Heart Summit, June 2024
5. Soheili F, Heydarikhorneh N, Stewart A., how to 9p21.3 contribute to coronary arterial calcification. Cardiovascular Research Day, April 2023
6. Soheili F, Heydarikhorneh N, Chen H, Stewart A., Bisphosphonate therapy worsens arterial calcification at MgpKO mice. Canadian Lipid & Vascular Summit, Sep 2023
7. Soheili F, Heydarikhorneh N, Chen H, Stewart A., Bisphosphonate therapy worsens arterial calcification at MgpKO mice. 66th Annual Canadian Society for Molecular Biosciences Meeting (CSMB 2023)
8. Soheili F, Dolatabadi F., Frequency of IVS II-1 β-thalassemia mutation in Baloch population of Chabahar city. 3rd international and 15th Iranian Genetics congress. May 13-15, 2018.
9. Asadollahi V, Soheili F., Neonate Mouse Liver Condition Medium Differentiate Mesenchymal Stem Cells Derived from Amniotic Membrane Placenta into Hepatocyte-like Cells In-vitro. The 2nd International and 4th National Congress of Wound Healing and Tissue Repair. October 25- 27th ,2017
10. Soheili F., Progress in applications of induced pluripotent stem cell technology. 1st International Joint Conference on New Trends in Biotechnology. April 18-19, 2017
12. Soheili F., Expression of GATA4, NKX2.5 and OCT4 Genes in Bone Marrow Stem Cells Treat with Algae Extract. International Congress on Stem Cells and Regenerative Medicine 20-22 May 2015 Mashhad, Iran
13. Soheili F, Heidary N., Comparison of Mesenchymal Stem Cell Isolation Efficiency from Murine Bone Marrow Cells, and Compact Bone. International Congress on Stem Cells and Regenerative Medicine 20-22 May 2015 Mashhad, Iran
JOURNAL REVIEWER (34 Articles)
https://www.webofscience.com/wos/author/record/AGP-0393-2022
PROFESSIONAL EXPERIENCE
2023-precent Member of Canadian Society for Molecular Biosciences (CSMB)
2023-precent Canadian Trainee representee in Communications and Publications Committee
https://csmb-scbm.ca/about-us/csmb-committees/communications-and-publications-committee/
2023-precent Editor board, Frontiers in microbiome: Nutrition, Metabolism, and the Microbiome
https://www.frontiersin.org/journals/microbiomes/editors
2023- precent Editor board, Cancer Cell International, spring nature, in progress
2008-2011 Member of Endocrinology and Genetic Diseases Committee, Medical University of Kurdistan, Kurdistan, Iran
2009-2011 Representative of Medical Education Development Center (EDC), Medical genetic Departments, Medical University of Kurdistan, Kurdistan, Iran
2002-2005 Member of Undergraduate Students' Union, Razi University
Teaching
2011-2018: Department of Biology, Chabahar Maritime University, Iran
Course: Genetics, Biochemistry, Cell and Molecular Biology
2007-2011: Department Medical Genetics, Medical University of Kurdistan, Kurdistan, Iran
Course: Medical Genetics, Genetic council, Molecular Biology
Timeline
Faculty Member (Researcher &Lecturer) - Faculty of Science Chabahar University
09.2011 - 08.2018
Research Scientist - Cellular and Molecular Research Center, KUMS,
09.2007 - 09.2011
Faculty Member (Researcher &Lecturer) - Medical University of Kurdistan
09.2007 - 09.2011
University of Ottawa, Faculty of Medicine - Ph.D., Biochemistry specialized in Human and Molecular Genetics
Shahid Chamran University of Ahvaz - M.Sc., Genetics
University of Razi - B.Sc., Biology
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