Suborno Jati

Dynamic Postdoctoral Researcher with extensive detailed research protocols and experiment experience. Analytical specialist with exemplary career record of manuscript preparation within critical deadlines. Collaborated with fellows, residents, and students to summarize findings and publish results in journals. Highly skilled Postdoctoral Researcher with comprehensive experience in biomedical research. Distinguished for innovative approaches, analytical problem-solving skills and deep understanding of scientific methodologies. Contributed significantly to address unanswered questions in the field. Demonstrated strong communication skills and collaborative spirit working effectively in diverse teams.

• 2009-2014 Ministry of Human Resource and Development (MHRD), Govt. of India Scholarship under the scheme of scholarships for college and university students according to the merit list
• 2014-2019 CSIR- Research Fellowship award
• 2016 Journal of Cell Biology Travelling Fellowship (JCSTF-161108) was awarded for three months of research at Dr. Victor Nizet’s Lab, University of California, San Diego.
• 2017-2018 Certificate of Appreciation from CSIR-Indian Institute of Chemical Biology for achieving excellence in research work during the year 2017-2018.
• 2022-2024. Holloway Postdoctoral Fellowship #2022-02 (end date: 31st May 2024)
• 2022 Selected as a speaker in Society for Neuroscience conference (Session type: Nanosymposium, Session title: Tau seeding and pathology in vivo models)

My Ph.D thesis focused mainly on elucidating the role of host factors in host-pathogen interaction. During my graduate studies, I found Wnt5A-mediated actin remodeling to be an essential regulator of autophagy-mediated killing of pathogenic bacteria. My finding on the role of Wnt5A in the containment of bacterial infection opened new avenues for future research, where Wnt5A has been proven to be a critical host factor for the survival of commensal gut bacteria. My graduate studies have resulted in 5 first authored publications.

During my postdoctoral studies I focused mostly on neuroinflammation and the effect of Chromogranin A on neurodegeneration. My Postdoctoral studies already resulted in one first author publication and other publications are in process.

1. Uncovering Wnt5A induced autophagy in host-pathogen interaction.

Wnt5A was known to affect bacterial phagocytosis by altering the cytoskeletal dynamics in macrophages. But whether Wnt5A can be instrumental in containment of bacterial pathogens was unknown. My study revealed the role of Wnt5A in autophagy mediated killing of pathogens like Pseudomonas sp, Streptococcus sp.

a. Jati, S., Kundu, S., Chakraborty, A., Mahata, S. K., Nizet, V., & Sen, M. (2018). Wnt5A signaling promotes defense against bacterial pathogens by activating a host autophagy circuit. Frontiers in immunology, 9, 679. PMID: 29686674; PMCID: PMC5900007.

b. Jati, S., Sarraf, T. R., Naskar, D., & Sen, M. (2019). Wnt Signaling: Pathogen Incursion and Immune Defense. Frontiers in immunology, 10, 2551. PMID: 31736969; PMCID: PMC6828841.

c. Jati, S., & Sen, M. (2019). Wnt Signaling Regulates Macrophage Mediated Immune Response to Pathogens. Macrophage Activation-Biology and Disease (Khalid Hussain Bhat Editor), p132.

2. Discovery of Wnt5A-Arp2 axis mediated actin modulation as a dictator to differentiate between pathogens and non-pathogens

Wnt5A regulates the phosphorylation of Arp2 and successive actin dynamics based on the pathogenic potential of the bacteria. This differentiated actin modulation affects the phagosomal maturation in the macrophages and results in killing of pathogenic bacteria but survival of non-pathogenic ones. This finding paved the way for further research where Wnt5A can be crucial for maintaining commensal in the gut.

a. Jati, S., Sengupta, S., & Sen, M. (2020). Wnt5A Signaling Mediated Cytoskeletal Actin Modulations Shape the Outcome of Host-Bacteria Interactions. The FASEB Journal, 34(S1), 1-1.

b. Jati, S., Sengupta, S., & Sen, M. (2021). Wnt5A Mediated Actin Organization Regulates Host Response to Bacterial Pathogens and Non-Pathogens. Frontiers in immunology, 11, 3803. PMID: 33664738; PMCID: PMC7921742.

3.  Wnt5A signaling in phagocytes in the gut helps in the survival of gut commensal

Wnt5A signaling is intrinsically associated with the fate of the bacteria inside the host based on its pathogenic potential. Further, we saw Wnt5A signaling is necessary for the survival of commensal in the gut phagocytes through actin remodeling and maintenance of T-cell homeostasis. This finding has enormous clinical significance in gastrointestinal disorders.

a. Sengupta, S., Jati, S., Maity, S., & Sen, M. (2022). Wnt5A Signaling Regulates Gut Bacterial  Survival and T cell Homeostasis. Msphere, 7(6), e00507-22. PMID: 36472447; PMCID: PMC9769580.

4. Analysis of antibody response in SARS-CoV-2 Infection and Vaccination in India

I was involved in a study to analyze the antibody response from plasma in a large cohort as an aftermath of the SARS-CoV-2 Infection in India.

a.  Ghosh, A., Saha, K., Das, A., Bhattacharjee, S., Pani, A., Shee, GG., Ray, P., Singh, D., Biswas, S.,  Murmu, S., Dutta, S., Dasgupta, A., Ghosh, A., Jati, S., Chattopadhyay, D., Sen, M., Ghosh, G. (2021). Antibody Development through SARS-CoV-2 Infection and Vaccination in India. J Infect Dis Epidemiol, 7, 219.

5. Exploring the function of Chromogranin A and its derived peptides in systemic metabolism

After joining UCSD, I started working with experts in granin biology (Dr. Sushil K. Mahata), inflammation (Dr. Gourisankar Ghosh) and tauopathy mediated neurodegeneration (Dr. Chen). I have contributed significantly to an ongoing work on the role of Chromogranin A in regulating systemic glucose metabolism, where we found that Chromogranin A-depleted mice develop improved insulin sensitivity with age.

a. Liu MA, Shahabi S, Jati S, Tang K, Gao H, Jin Z, Miller W, Meunier FA, Ying W, van den Bogaart G, Ghosh G, Mahata SK. (2022). Gut microbial DNA and immune checkpoint gene Vsig4/CRIg are key antagonistic players in healthy aging and age-associated development of hypertension and diabetes. Front Endocrinol (Lausanne). 13:1037465. PMID: 36440192; PMCID: PMC9691654.

b. Jati S, Mahata S, Das S, Chatterjee S, Mahata SK (2023). Catestatin: Antimicrobial Functions and Potential Therapeutics. Pharmaceutics. 15(5):1550. doi: 10.3390/pharmaceutics15051550. PMID: 37242791; PMCID: PMC10220906.

6. Exploring the function of Chromogranin A and its derived peptides in tauopathy mediated neurodegeneration

During my postdoctoral tenure I did a comprehensive study on the role of Chromogranin A and derived peptides on tauopathy mediated neurodegeneration in PS19 mouse model. I found that depletion of Chromogranin A is beneficial for attenuating tauopathy mediated neurodegeneration.

a. Jati, S., Munoz-Mayorga, D., Shahabi, S., Tang, K., Tao, Y., Dickson, D. W., ... & Chen, X. (2025). Chromogranin A deficiency attenuates tauopathy by altering epinephrine–alpha-adrenergic receptor signaling in PS19 mice. Nature Communications, 16(1), 1-18. PMID: 40393970; PMCID: PMC12092710.

Book Chapter

1. Jati, S., & Sen, M. (2019). Wnt signaling regulates macrophage mediated immune response to pathogens. Macrophage Activation-Biology and Disease.

Conference papers

1. Jati, S., Sengupta, S., & Sen, M. (2020). Wnt5A Signaling Mediated Cytoskeletal Actin Modulations Shape the Outcome of Host‐Bacteria Interactions. The FASEB Journal, 34(S1), 1-1.

2. Mahata, S. K., Liu, M. A., Jati, S., Tang, K., Bogaart, G., & Ghosh, G. (2022). Chromogranin A plays a crucial role in age‐related development of insulin resistance and hypertension. The FASEB Journal, 36.