Shao-Yuan Chen

Experienced medical professional with a proven track record as a Medical Director in a reputable teaching hospital. Accomplished Associate Professor in a prestigious medical school, contributing to the education and development of future healthcare professionals. Recognized as a Distinguished Consultant in the field of drug development, providing valuable expertise and guidance to pharmaceutical companies. Adept at leveraging extensive knowledge and skills to drive advancements in patient care, education, and research.

• Society for Neuroscience (1997-)
• Chinese Immunology Society (1996-)
• American Association of Immunology (1996-)

• Director, 2008, Hyperbaric Medical Center, Cardinal Tien Hospital, New Taipei city, Taiwan, Republic of China
• Director, 2009, Medical Research Center, Cardinal Tien Hospital, New Taipei city, Taiwan, Republic of China
• Associate Professor, 2010, School of Medicine, Fu Jen Catholic University, New Taipei city, Taiwan, Republic of China
• Part-time Associate Professor, 1999, Institute of Undersea and Hyperbaric Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China
• Part-time Attending Physician, 2000, Department of Neurology, Tri-Service General Hospital, Taipei, Taiwan, Republic of China
• Chair, Attending Physician, 2003, 2004, Department of Undersea and Hyperbaric Medicine, Tri-Service General Hospital, Taipei, Taiwan, Republic of China

• Date of Birth: 01/01/65
• Gender: Male

• Tseng C-J, Chen S-Y, Tao P-L, Chern J-W, and Yen M-H, Antihypertensive effects of AT-112, a newly synthesized Quinazoline derivative, in SH rats, Proceeding of National Science Council, ROC, 19, 3, 159-65, 1995
• Takeoka Y., Whitmer K.J., Chen S-Y, Ansari A.A., Boyd R.L., Shultz L.D., Suehiro S., and Gershwin M.E., Thymic epithelial cell abnormalities in (NZB x H-2u) F1 mice, Clinical Immunology and Immunopathology, 76, 3 Pt 1, 297-307, 1995
• Takeoka Y., Chen S-Y, Yago H., Boyd R.L., Suehiro S., Shultz L.D., Ansari A.A., and Gershwin M.E., The murine thymic microenvironment: changes with age, International Archive of Allergy Immunology, 111, 5-12, 1996
• Chen S-Y, Takeoka Y., Ansari A.A., Boyd R., Klinman D.M., and Gershwin M.E., The natural history of disease expression in CD4 and CD8 gene-deleted New Zealand Black (NZB) mice, Journal of Immunology, 157, 2676-2684, 1996
• Chen S-Y, Takeoka Y., Larry Pike-Nobile, Ansari A.A., Boyd R., and Gershwin M.E., Autoantibody production and cytokine profiles of MHC class I (β2-microglobuline) gene deleted New Zealand Black (NZB) mice, Clinical Immunology and Immunopathology, 84, 3, 318-327, 1997
• Chen S-Y, Takeoka Y., Larry Pike-Nobile, Ansari A.A., Boyd R., and Gershwin M.E., Natural history of disease expression in MHC class I (β2-microglobuline) gene deleted New Zealand Black (NZB) mice, Journal of Allergy and Clinical Immunology, 99, 1, Abstracts S19, 1997
• Takeoka Y., Chen S-Y, Boyd R.L., Tsuneyama K., Taguchi N., Morita S., Yago H., Suehiro S., Ansari A.A., Shultz L.D., and Gershwin M.E., A comparative analysis of the murine thymic microenvironment in normal, autoimmune and immunodeficiency states, Development Immunology, 5, 2, 79-89, 1997
• S.Y. Chen, H.P. Hsu, and Y.C. Chen, The effect of hyperbaric oxygen on autoimmune disease NZB/W F1 mice, Undersea & Hyperbaric Medicine, 29, 2, p128, 2002
• Huang, K.L., C.P. Wu, W.C. Perng, and S.Y. Chen, Hyperbaric oxygen therapy for carbon monoxide intoxication in a case of thermal inhalation injury, Thorax Med, 18, 493-499, 2003
• Chen S-Y, Chen Y-C, Wang J-K, Hsu H-P, and Sytwu H-K, Early application of hyperbaric oxygen therapy ameliorates the severity of disease development on lupus-prone autoimmune (NZB x NZW) F1 mice, Clin Immunol, 180, 2, 103-110, 2003
• Su CL, Wu CP, Chen SY, Kang BH, Huang KL, Lin YC, Acclimatization to neurological decompression sickness in rabbits, Am J Physiol Regul Integr Comp Physiol, 287, 5, R1214-8, 2004
• Lin Y-C, Chen S-Y, Huang K-L, Scientific rationale of hyperbaric oxygen therapy for osteoradionecrosis of the jaw, Chin Dent J, 24, 1, 1-14, 2005
• Tsuneyama K, S.Y. Chen, Cheng C, and Takano Y, Etiopathogenesis of primary biliary cirrhosis with an emphasis on microbial participation, J Med Sci, 26, 2, 045-054, 2006
• Yen-Chen Chen, Shao-Yuan Chen, Pey-Shen Ho, Chia-Huei Lin, Ya-Yuan Cheng, Jehng-Kang Wang and Huey-Kang Sytwu, Apoptosis of T-leukemia and B-myeloma cancer cells induced by hyperbaric oxygen increased phosphorylation of p38 MAPK, Leukemia Research, 31, 6, 805-815, 2007
• C.-P. Lo, S.-Y. Chen, M.-C. Chou, C.-Y. Wang, K.-W. Lee, C.-J. Hsueh, C.-Y. Chen, K.-L. Huang, G.-S. Huang, Diffusion-tensor MR imaging for evaluation of the efficacy of hyperbaric oxygen therapy in patients with delayed neuropsychiatric syndrome caused by carbon monoxide inhalation, European Journal of Neurology, 14, 7, 777–782, 2007
• Lo, C. P., Chen, S. Y., Lee, K. W., Chen, W. L, Chen, C. Y., Hsueh, C. J., Huang, G. S., Brain injury after acute carbon monoxide poisoning: early and late complications, Am J Roentgenol, 189, 4, 205-211, 2007
• Jiun-Liang Chen, Yen-Chen Chen Chen, Shien-Hong Yang, Shao-Yuan Chen
• Immunological alterations in lupus-prone autoimmune (NZB / NZW) F1 mice by mycelia Chinese medicinal fungus Cordyceps sinensis induced redistributions of peripheral mononuclear T lymphocytes, Clinical and Experimental Medicine, 9, 277-284, 2009
• Chung-Ping Lo, Hung-Wen Kao, Shao-Yuan Chen, Chun-Jen Hsueh, Wei-Chen Lin, I-Chan Chiang, Ding-Kwo Wu, and Gin-Chung Liu, Prediction of conversion from clinically isolated syndrome to clinically definite multiple sclerosis according to baseline MRI findings: comparison of revised McDonald criteria and Swanton’s modified criteria, Journal of Neurology, Neurosurgery & Psychiatry, 80, 7, 1107-1109, 2009
• Kai-Chen Wang, Ching-Piao Tsai, Chao-Lin Lee, Shao-Yuan Chen, Symptomatic, radiological and pathological involvement of the hypothalamus in neuromyelitis optica- Brainstem involvement in neuromyelitis optica, Journal of Neurology, Neurosurgery & Psychiatry, 80, 679-682, 2009
• D.C. Chang, J.T. Lee, C.P. Lo, Y.M. Fan , K.L. Huang, B.H. Kang, H.L. Hsieh, S.Y. Chen
• Hyperbaric oxygen ameliorates delayed neuropsychiatric syndrome of carbon monoxide poisoning, UNDERSEA & HYPERBARIC MEDICINE, 37, 23-33, 2010
• Vinchi Wang, Shao-Yuan Chen, Tzu-Chao Chuang, Din-E Shan, Bing-Wen Soong, Ming-Ching Kao, Val-9Ala and Ile+58Thr polymorphism of MnSOD in Parkinson's disease, Clinical Biochemistry, 43, 979–982, 2010
• Shao-Yuan Chen, Chung-Ping Lo, Wen-Lin Hsu ,Hung-Wen Kao, Chun-Jen Hsueh, Wei-Chen Lin,Chia-Chen Liu, Wei-Yu Wang and Chia-Chun Hsu, Modifications to the McDonald MRI dissemination in space criteria for use in Asians with classic multiple sclerosis: the Taiwanese experience, Multiple Sclerosis, 16, 10, 1213–1219, 2010
• Kai-Chen Wang, Ching-Piao Tsai, Chao-Lin Lee, Shao-Yuan Chen, Shyi-Jou Chen, The Prevalence of Long Spinal Cord Lesions and Anti-Aquaporin 4 Antibodies in Neuromyelitis Optica Patients in Taiwan, European Neurology, 65, 2, 99-104, 2011
• Kai-Chen Wang, Chao-Lin Lee, Shao-Yuan Chen, Kuan-Hsiang Lin, Ching-Piao Tsai, Glatiramer acetate could be a hypothetical therapeutic agent for Neuromyelitis optica, Medical Hypotheses, 76, 820-822, 2011
• Wang KC, Lee CL, Chen SY, Lin KH, Tsai CP, Prominent brainstem symptoms/signs in patients with neuromyelitis optica in a Taiwanese population, Journal of Clinical Neuroscience, 18, 9, 1197-200, 2011
• Koichi Tsuneyama, Yen-Chen Chen, Makoto Fujimoto, Yoshiyuki Sasaki, Wataru Suzuki, Tsutomu Shimada, Sei-ichi Iizuka, Mitsunobu Nagata, Masaki Aburada and Shao-Yuan Chen
• Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis, TheScientificWorldJOURNAL, 11, 2124-2135, 2011
• Cheng-Hsin Chen, Shao-Yuan Chen
• Vinchi Wang, Chao-Ching Chen, Kaw-Chen Wang , Chih-Hao Chen, Yi-Chien, Liu, Kuo-Cheng Lu, Ping-Keung Yip, Wen-Ya, Ma, Chuan-Chieh Liu, Effects of repetitive hyperbaric oxygen treatment in patients with acute cerebral infarction - A pilot study, TheScientificWorldJOURNAL, 2012
• Makoto Fujimoto, Koichi Tsuneyama, Shao-Yuan Chen, Takeshi Nishida, Jiun-Liang Chen, Yen-Chen Chen, Takako Fujimoto, Johji Imura, Yutaka Shimada, Study of the effects of monacolin k and other constituents of red yeast rice on obesity, insulin-resistance, hyperlipidemia, and nonalcoholic steatohepatitis using a mouse model of metabolic syndrome, Evidence-based Complementary and Alternative Medicine, 2012, 892697
• Wang KC, Tsai CP, Lee CL, Chen SY, Chin LT, Chen SJ, Elevated plasma high-mobility group box 1 protein is a potential marker for neuromyelitis optica, Neuroscience, 226, 510-6, 2012
• Kai Chen Wang, Chao-Lin Lee, Shao-Yuan Chen, Jeen-Chen Chen, Chih-Wen Yang, Shyi-Jou Chen, Ching-Piao Tsai, Distinct serum cytokine profiles in neuromyelitis optica and multiple sclerosis, Journal of interferon & cytokine research, 33, 2, 58-64, 2013
• Chun-Jen Hsueh , Hung-Wen Kao, Shao-Yuan Chen, Chung-Ping Lo, Chia-Chun Hsu, Dai-Wei Liu , Wen-Lin Hsu, Comparison of the 2010 and 2005 versions of the McDonald MRI criteria for dissemination-in-time in Taiwanese patients with classic multiple sclerosis, Journal of the Neurological Sciences, 329, 51–54, 2013
• Kai-Chen Wang, Ching-Piao Tsai, Chao-Lin Lee, Shao-Yuan Chen, Gu-Jiun Lin, Mao-Hsiung Yen, Huey-Kang Sytwu and Shyi-Jou Chen, Alpha lipoic acid enhances endogenous peroxisome proliferator-activated receptor-γ to ameliorate experimental autoimmune encephalomyelitis, Clinical Science, 2013