Sadaf Rahimi
Montreal,QC
Overview
3
3
years of professional experience
Work History
Downstream Process Development Lead
Nivad Pharmed Salamat
12.2019 - 07.2021
- Led end-to-end development and optimization of purification process of the adjuvant for HPV vaccine (Papilloguard), from initial R&D to cGMP manufacturing and technology transfer.
- Was the key contributer to the design and implementation of downstream processing steps including chromatography, sterile filtration, and QC testing protocols.
- Troubleshot purification challenges and suggested creative solutions to optimize process robustness and yields.
- Provided hands-on training for production team on all downstream processing and analytical methods.
- Established SOPs and qualification protocols ensuring alignment with USP guidelines and FDA regulations.
- Managed technology transfer and scale-up to enable large-scale cGMP production of adjuvant.
- Recognized for technical expertise in bioprocessing and ability to lead cross-functional teams.
Downstream Process Development Scientist
MOM Research And Innovation Center
12.2018 - 08.2019
- Developed and optimized downstream purification process for lentiviral vectors used in CAR-T cancer immunotherapies for ALL and DLBCL.
- Conducted comprehensive literature review of viral vector processing techniques. Gained hands-on experience with chromatography, filtration, and TFF operations.
- Wrote vector production and purification sections for project proposals. Provided solutions for technical challenges through brainstorming sessions.
Research Intern
Virology Lab, University Of Tehran
01.2019 - 09.2019
- Gained hands-on experience in viral vector production
- Produced retroviral and lentiviral vectors using plasmid transfection of HEK293T cells.
- Performed vector concentration and characterization via qPCR.
- Assisted with cell culture, transfection, and analytical testing to support vector process development.
- Developed technical skills in working under biosafety conditions and maintaining aseptic techniques.
Education
Graduate Certificate - Science And Technology Commercialization
Simon Fraser University
Vancouver, BC08.2024
Master of Science - Biomedical And Molecular Sciences
Queen’s University
Kingston, ON08.2023
Bachelor of Science - Biotechnology
University of Tehran
Tehran, Iran01.2020
Skills
- Chromatography techniques (Acta systems)
- Filtration techniques (Cross flow TFF system)
- Flow Cytometry and cell sorting
- Multiplex Immunofluorescence Staining
- Mammalian cell culture and Transfection
- Designing Primers, PCR methods, Blotting, Gene cloning, ELISA
- Familiar with Instrumental Analytical Methods and Spectrophotometry
Timeline
Downstream Process Development Lead
Nivad Pharmed Salamat
12.2019 - 07.2021
Research Intern
Virology Lab, University Of Tehran
01.2019 - 09.2019
Downstream Process Development Scientist
MOM Research And Innovation Center
12.2018 - 08.2019
Graduate Certificate - Science And Technology Commercialization
Simon Fraser University
Master of Science - Biomedical And Molecular Sciences
Queen’s University
Bachelor of Science - Biotechnology
University of Tehran
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