ROCHI SAURABH
Waterloo,ON
Summary
Doctoral researcher in genomics and computational biology with a focus on genetic and immune-related patterns in autoimmune diseases. Achievements include applying AI to multi-omics data for cancer survival and grade prediction, as well as investigating GPCR-related gene expression in glioma. Expertise in data integration, risk score analysis, and biomarker discovery supports the advancement of personalized therapeutic strategies. Committed to leveraging research to enhance understanding and treatment of complex diseases.
Overview
8
8
years of professional experience
Work History
Doctoral Researcher
University of Lübeck
Lübeck, Germany
12.2021 - 08.2025
- Identified comorbidity patterns indicating partial genetic overlap.
- Gender differences are evident in the prevalence of certain autoimmune conditions.
- Discovered new and recognized genes associated with autoimmune disorders.
- Analyzed differences in systemic and localized immune involvement across various diseases.
- Identified notable population-specific associations for pemphigus and related autoimmune diseases.
Research Fellow
Indian Institute of Science
Bangalore, India
11.2020 - 10.2021
- Worked on genetic and epigenetic changes in brain cancer (glioma).
- Performed integrated study on expression patterns of GPCRs, their ligands, and related Gα proteins in glioma.
Research Fellow
CSIR-National Chemical Laboratory
Pune, India
10.2018 - 04.2020
- Focused on somatic mutation and omics datasets for cancer prognosis.
- Used artificial intelligence for survival and grade prediction.
- Connected predictive data to appropriate drug administration.
- Identified key factors to enhance therapeutic and personalised treatment designs.
Summer Trainee
CSIR-Centre for Cellular and Molecular Biology
Hyderabad, India
05.2017 - 07.2017
- Investigated EGFR-Tyrosine Kinase Domain mutations and associated drug resistance.
- Analyzed the effects of single, compound, insertion, and deletion mutations.
- Studied their impact on the binding of first-, second-, and third-generation EGFR inhibitors.
Education
Ph.D. - Systems Biology
University of Luebeck
Germany08-2025
Master of Science - Bioinformatics
Central University of South Bihar
Gaya, India01.2018
Bachelor of Science - Biotechnology
Anugrah Narayan College
Patna, India01.2016
Skills
- Data analysis on CNV, transcriptome dataset, methylome, whole exome sequence, artificial intelligence, GWAS analysis, differential gene expression, pathway enrichment, network propagation, and PCA analysis
- Databases: TCGA, UK Biobank, TriNetX, GWAS, and PGS catalog, EFO
- Programming: (Perl, R (advanced), C, Python (basic))
Publications
1. Saurabh, Rochi, Anikamila Cani, Marius Möller, and Hauke Busch. "Large-scale global retrospective study on the interaction between ancestry and risk of comorbid autoimmune diseases in patients with pemphigus." Scientific Reports 14, no. 1 (2024): 1-8. (Published)
2. Saurabh, Rochi, Césaire JK Fouodo, Inke R. König, Hauke Busch, and Inken Wohlers. "A survey of genome-wide association studies, polygenic scores and UK Biobank highlights resources for autoimmune disease genetics." Frontiers in immunology 13 (2022): 972107. (Published)
3. Ohmes, Justus, Afsaneh Mehrpouyan, Julia Wimmer-Groß, Abdul Razzaque Ahmed, Kyle T. Amber, Swayanka Biswas, Angela Christiano et al. "Meeting Report on “The International Congress on Autoimmune Pre-disease (2024)”." JID Innovations 5, no. 3 (2025): 100342. (Published)
4. K.D. Reddy, Y. Maluje, F. Ott, A. Schaaf, A. Bohnhorst, S.B. Biedermann, R. Saurabh, J. Pierstorf, S. Winkelmann, B. Voß, M. Laudien, T. Bahmer, J. Heyckendorf, F. Brinkmann, S. Schreiber, W. Lieb, K.F. Rabe, C.A. Jakwerth, C. Schmidt-Weber, G. Hansen, A.M. Dittrich, E. von Mutius, N. Maison, B. Schaub, M.V. Kopp, H. Busch, M. Weckmann, A. Fähnrich and the ALLIANCE Study Group as part of the German Centre for Lung Research (DZL), scRNA-seq reveals persistent aberrant differentiation of nasal epithelium driven by TNF and TGF in post-COVID syndrome, Nature Communications (Revised manuscript submitted)
Affiliations
- Supervision of a bachelor’s thesis
- Organization of seminars
Timeline
Doctoral Researcher
University of Lübeck
12.2021 - 08.2025
Research Fellow
Indian Institute of Science
11.2020 - 10.2021
Research Fellow
CSIR-National Chemical Laboratory
10.2018 - 04.2020
Summer Trainee
CSIR-Centre for Cellular and Molecular Biology
05.2017 - 07.2017
Ph.D. - Systems Biology
University of Luebeck
Master of Science - Bioinformatics
Central University of South Bihar
Bachelor of Science - Biotechnology
Anugrah Narayan College
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