Summary
Overview
Work History
Education
Skills
Accomplishments
Certification
Publications
Timeline
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Pournami Ramachandran

Summary

Accomplished postgraduate cancer researcher with a solid foundation in biomedical science and molecular medicine. Proficient in molecular and cellular biology, possessing a strong understanding of research methodologies. Passionate about the convergence of science and healthcare, specifically in oncology, therapeutics, and pharmaceutical advancements.

Overview

4
4
years of professional experience
1
1
Certification

Work History

Research Intern

Centre for Cellular and Molecular biology
01.2024 - Current
  • Biomarker discovery in breast cancer, identifying and validating potential miRNAs through in vitro and in vivo studies.
  • Using Apc fl/fl Knockout Murine Models to evaluate the anti-cancer potential of RNAi-Based Combinatorial Bio-Drug Therapies.
  • Working towards investigating the role of CITED-1 in colorectal cancer progression. Histological studies using different staining techniques.

Master's Dissertation

Amrita School of Nanosciences and Molecular Medicine
08.2021 - 07.2023
  • Conducted expression profiling of long noncoding RNAs (lncRNAs) in breast cancer patients undergoing pre-operative endocrine therapy, focusing on their role in treatment response and disease progression.
  • Analyzed data from Indian women with breast cancer to identify lncRNA biomarkers associated with therapeutic outcomes, contributing to personalized medicine approaches for breast cancer management.

B.Sc (Hons) Project Work

Nitte University Centre for Science Education and Research
01.2021 - 08.2021
  • Investigated the interaction between microplastics and pathogens, emphasizing their environmental and health impacts.
  • Collected and analyzed microplastic samples using FTIR spectroscopy for characterization and further identified clinically significant pathogens using PCR.

Education

Master of Science - Molecular Medicine

Amrita School of Nanosciences and Molecular Medicine
07.2023

Bachelor of Science (Hons) - Biomedical Science

Nitte University Centre for Science Education and Research
08.2021

Higher Secondary Education - undefined

Christ CMI Public School
03.2017

Skills

  • DNA/RNA extraction
  • PCR
  • QPCR
  • RT-PCR
  • Cell culture handling
  • Transfection
  • Invitro assays
  • Western blot
  • Cryosectioning
  • Mice handling
  • Tissue staining techniques
  • Immunocytochemistry
  • Tissue processing
  • Embedding
  • Compound Microscope
  • Stereomicroscope
  • Confocal Microscopy
  • Linus
  • Pymol
  • Chemsketch
  • BLAST-NCBI
  • SWISS-PROT
  • MS Excel
  • MS Word
  • Microsoft PowerPoint
  • Presentation
  • Research article writing
  • Review writing
  • Data analysis
  • Image J
  • GraphPad Prism

Accomplishments

  • Engaged in collaborative research with IIIM Jammu focused on process standardization and development of an antibiotic-based therapeutic for colorectal cancer.
  • Successfully established a stable MCF-7 breast cancer cell line to evaluate the tumor-promoting role of specific miRNAs.

Certification

  • Cancer Biology Workshop, 2-day offline workshop on 'Cancer Biology' at IISc Bangalore.
  • Dashabda Conference Delegate, Conference on CME on High-risk Hematology, BMT and Cellular Therapy.

Publications

Small-molecule inhibitors of WNT signalling in cancer therapy and their links to autophagy and apoptosis, European Journal of Pharmacology, Provides a comprehensive understanding of the role of the WNT/β-catenin signaling pathway in cancer, emphasizing its regulation of autophagy and apoptosis, while highlighting the potential of specific small molecule inhibitors targeting this pathway to foster the development of novel, tailored cancer treatments.

Timeline

Research Intern

Centre for Cellular and Molecular biology
01.2024 - Current

Master's Dissertation

Amrita School of Nanosciences and Molecular Medicine
08.2021 - 07.2023

B.Sc (Hons) Project Work

Nitte University Centre for Science Education and Research
01.2021 - 08.2021

Bachelor of Science (Hons) - Biomedical Science

Nitte University Centre for Science Education and Research

Higher Secondary Education - undefined

Christ CMI Public School

Master of Science - Molecular Medicine

Amrita School of Nanosciences and Molecular Medicine

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Pournami Ramachandran