Contributed to the MRI study of early normal brain development funded by the National Institutes of Health.
Projects:
- Image fusion algorithm and its role in longitudinal MRI study of early brain development
— Developed a multi-resolution image fusion algorithm that effectively combines information from different MR brain image types into a single image with enhanced anatomical features
— Created representative fused templates of pediatric MR dataset of early brain development and showed a role of image fusion in longitudinal study.
- Local semi-supervised and perceptual image quality-based approach to automatic brain tissue classification in young children
— Introduced a new philosophy of brain tissue classification without ground truth using modern pattern recognition and perceptual image quality models in Computer Vision to allow detection of tissue patterns with an accuracy of the Human Visual System
— Developed a regional version of the proposed classification approach that accommodates highly varying within-class MR signal intensities and improves detection of small brain structures in low-contrast regions
— Designed and analyzed an algorithm based on a novel regional classification methodology and implemented it to pediatric MR dataset of early brain development
— Extended the methodology to identification of myelinated and unmyelinated white matter subclasses in early infancy period from 0 to 6 months of age.