Nady Mettias
Oceanside,CA
Summary
SAMPLE MANAGEMENT AND AUTOMATION PROFESSIONAL A strong knowledge and understanding of small molecule drug discovery processes. Expertise in process design, automated sample management, liquid handling, integrated data handling, and informatics integration. Proven skills in developing and implementing efficient workflow processes, and success in leading teams in a matrix environment. Demonstrated experience working with multiple customer groups to deliver solutions. Holistic understanding of scientific and non-scientific Research Operations and systems (e.g., EH&S, Import&Export, Facilities, Lab Ops) with the ability to develop strategic cohesive operational solutions.
Overview
23
23
years of professional experience
1
1
Certification
Work History
Head of Global of Compound Management and Laboratory Automation
Takeda Pharmaceutical Company
01.2020 - Current
- Manage and mentor teams of sample management professionals across Takeda’s research sites in Boston, San Diego and Japan
- Direct the functional operations for small molecule and biologics management and drive continuous operational improvement and innovation
- Define and shape Sample Management objectives and KPIs, outsourcing strategy and budget goals
- Act as strategic partner across multiple research functions and external collaborations (e.g., Drug Discovery Units, Global Biologics, Import&Export, Quality, Finance Procurement, IT and Facilities)
- Oversaw the planning, design, sourcing, development, implementation, and maintenance of high-throughput laboratory workflows, automation systems and technical infrastructure including mobile robots, Global Compound Inventory System, Global Compound Compliance System, and integration to Global Trade Management System
- Member of Takeda’s DE&I CAUSE Network to develop strategy, education and training, and raise awareness for a more diverse, inclusive, and equitable workplace
- Accountable for the development of organizational culture and capabilities
- Member of Takeda-San Diego Site Leadership Team
- Member of Takeda-San Diego Site Tours Team.
Associate Director – Compound Management, Lab Ops and Research Informatics
Gossamer Bio
01.2018 - 01.2020
- Leading role in launching entire Gossamer R&D research infrastructure from lab space design and equipment sourcing to building a winning team and culture
- Defined and implemented detailed, comprehensive and well-structured early-stage start-up workflows across multiple disciplines such as compound and reagent inventory management, shipping and receiving, asset management and EH&S ensuring research laboratories operational efficiency and effectiveness
- Act as key interface between research lab personnel with IT, Facilities and Procurement
- Participated in requirements gathering and business analysis activities to select, validate and implement research informatics platform including ELN, compound registration and inventory control systems
- Manage lab safety, budget, inventory and operational aspects of all laboratory services
- Collaborate effectively with vendors and CROs to meet deliverables within expected timeline.
Associate Director - Sample Management and Research Systems
Allergan
01.2015 - 01.2018
- Managed all aspects of Sample Management and Research Systems across Allergan R&D
- Contributed to company-wide strategic initiatives of “Open Science” through mergers, acquisitions and partnership
- Provided leadership in the due diligence and integration plan to define assets, capabilities and maximize synergy in the combined company
- Managed the timely inclusion of the compound assets from mergers and acquisitions into Allergan’s Compound Logistics
- Ensured accurate transfer of related electronic files
- Worked closely Allergan’s Global Trade Compliance Group and EHS to manage the shipping of screening compounds to and from multiple research sites and CRO’s across the globe
- Acted as the business owner for Allergan Freezer Remote Monitoring System, Allergan Global Chemical Reagent Inventory Tracking System
- Involved in the design and build and deployment of Allergan Select-Agent Inventory System
- Participated on multidisciplinary Working Groups and Functional Steering Committees to assess emerging technologies strategies in IT and Digital Health Initiatives.
Senior Manager - Compound Management and Automation
Allergan
01.2010 - 01.2015
- Oversaw the design and construction of a new Compound Management System (CMS) facility to be at the cutting edge of science and automation that will enable essential processes such as: New compound inclusion, Sample QA/QC including LC-MS qualitative analysis, Single point and dose response assay ready plates, Powder weighing, Screening deck production, Compound requisition and distribution workflows, Top to bottom inclusive electronic data tracking
- Acted as primary interface between chemists and biologists to implement compound management workflows that ensure uninterrupted flow and processing of samples provided by chemists in support of lead identification and optimization
- Interfaced with RDIS organization for delivering IT projects related to CMS and other Discovery projects ensuring customer requirements are met within service level agreements to the highest quality
- Led cross-functional internal and external teams to harmonize compound logistics processes throughout the Allergan network for building best-in-class screening collection
- Managed project schedules and allocate the appropriate resources necessary to complete projects on time
- Planned and monitored the CMS group CE and operating budget
- Ensured purchase orders are funded and goods are received
- Operated and maintained fully automated compound storage and retrieval system with capacity of over 30 million research samples.
Senior Scientist - Compound Management / Automation
Neurocrine Biosciences
01.2004 - 01.2010
- Executed all the functions of Compound Management including sample registration, plating, reformatting, storage and fulfill requests for retrieval and distribution
- Led a team of scientists and engineers responsible for the design, evaluation, purchase and implantation of an automated compound storage and retrieval system
- Represented Neurocrine Biosciences in the Factory Acceptance Test (FAT) and Site Acceptance Test (SAT) of the 100,000-plate (110 million tubes) capacity storage and retrieval system
- Interacted with biologists, chemists, and IT to improve the quality of the corporate compound collection and the processes for compound acquisition
- Worked with a third-party software development company to design, test and deploy a web-based Compound Archive and Management System for compound requisition and compound inventory control
- Served as Team Leader for the Compound Management team, developing compound handling and storage processes and ensuring timely delivery of compound plates to the HTS, Preclinical, Pharmacology, and Chemistry project teams
- Served on multi-disciplinary teams that defined company strategies for compound quality, management and distribution paradigms
- Developed compounds QC/QA through LCMS and stability assays
- Worked with IT to develop a seamless method to register compound templates into Activity Base
- Wrote many Visual Basic and Accelrys’s Pipeline Pilot programs as in-house Screening and compound management tools
- Integrated a variety of laboratory equipment and wrote the necessary scripts to run them.
Scientist - Lead Discovery Department / HTS
Neurocrine Biosciences
01.2001 - 01.2004
- Hands-on experience in assay development, automation and screening of cell-based assays and biochemical assays
- Experienced in developing assays with absorbance, fluorescence, time-resolved fluorescence, radiometric and fluorescence polarization readout.
Education
Bachelor of Science - Molecular Genetics and Computer Information Systems
Ohio State University
Columbus, OhioSkills
- Time Management
- Flexible and Adaptable
- Critical Thinking
- Multitasking Abilities
- Dependable and Responsible
- Decision-Making
- Problem Resolution
Websites
Certification
- Society for Laboratory Automation and Screening (SLAS) member
- International Society of Biological and Environmental Repositories (ISBER) member
- Laboratory Robotics Interest Group (LRIG)
- Liquid Handling Robotics Group
Timeline
Head of Global of Compound Management and Laboratory Automation
Takeda Pharmaceutical Company
01.2020 - Current
Associate Director – Compound Management, Lab Ops and Research Informatics
Gossamer Bio
01.2018 - 01.2020
Associate Director - Sample Management and Research Systems
Allergan
01.2015 - 01.2018
Senior Manager - Compound Management and Automation
Allergan
01.2010 - 01.2015
Senior Scientist - Compound Management / Automation
Neurocrine Biosciences
01.2004 - 01.2010
Scientist - Lead Discovery Department / HTS
Neurocrine Biosciences
01.2001 - 01.2004
Bachelor of Science - Molecular Genetics and Computer Information Systems
Ohio State University
Similar Profiles
Matthew CochraneMatthew Cochrane
Quality Management Representative at Takeda Pharmaceutical CompanyQuality Management Representative at Takeda Pharmaceutical Company
Waldemar KendrickWaldemar Kendrick
Manufacturing Trainer at Takeda Pharmaceutical Company LimitedManufacturing Trainer at Takeda Pharmaceutical Company Limited
MATT DIASMATT DIAS
Manufacturing Technician at Takeda Pharmaceutical Company LimitedManufacturing Technician at Takeda Pharmaceutical Company Limited