Nicolas Ho
Postdoctoral Fellow
Ottawa
Summary
PhD-trained scientist with expertise in translating complex biological problems into actionable insights through cutting-edge computational approaches. Currently advancing single-cell genomics research as a Postdoctoral Scientist, specializing in machine learning applications and multi-omics data integration with a strong desire to advance my career in a related industry.
Overview
8
8
years of professional experience
1
1
Certification
3
3
Languages
Work History
Postdoctoral Researcher
University of Ottawa
08.2024 - Current
- Investigating changes in the immunological landscape following exposure to low dose radiation via scRNA-seq analyses. Partnered with the Canada Nuclear Laboratory. Recipient of the MITAC elevate award (CA 120,000 ~ 2025 - 2027)
- Investigating next generation cancer treatment response in triple negative breast cancer (and potentially more cancer types) with researchers from Health Canada via scRNA-seq analyses.
- Investigating hematopoietic stem cell chemotherapy resistance in acute myeloid leukemia. Collaborating with a well know lab from University of Toronto.
- Designed and implemented enhanced visualization to present high-dimensional data in scRNA-seq analyses.
- Provide troubleshooting to summer attachment Undergraduate students, Master students, and Ph.D. students for scRNA-seq analyses related problems (mainly for optimization of PCA, annotation, annotation validation, visualization) etc.
- Unix (Alignment of 10X/DropSeq/MicrowellSeq .fastq data), R(Seurat, TooManyCells, SCTransform, Monocle3, SCENIC, Cellchat, Caret etc.)
- Evaluate student performance during conferences/symposium or other academic events.
- HPC via compute Canada to mainly transfer files between collaborating institutions.
Clinical Research Internship
The Chinese University of Hong Kong
06.2017 - 06.2019
- Optimization of in-vitro-in-vivo correlations (IVIVC) to facilitate generic drug development for the local pharmaceutical industry.
- Evaluated pharmacokinetics, pharmacodynamics, cytotoxicity via surgeries (surgeries, monitoring, cell-culture, dissolution experiments, protein purification and mass spectrometry)
- Designed and implemented clinical trials for Phase One evaluation of the developed generic drugs (Metformin, Diclofenac, Potassium) at the Prince of Wales Hospital.
- Liaised between multiple academic, healthcare professionals and industrial parties to facilitate progress.
Education
Ph.D. - Biomedical Sciences
The Chinese University of Hong Kong
Hong Kong 05.2001 -
Master of Science - Biomedical Engineering
The Chinese University of Hong Kong
Hong Kong 05.2001 -
Bachelor of Engineering - Biomedical Engineering
City University of Hong Kong
Hong Kong 05.2001 -
Skills
- scRNA-seq fastq alignments (Unix: 10X, Dropseq, Microwell seq)
- scRNA-seq analyses (R: Seurat, SCTransform, PCA, FindClusters/TooManyCells, annotation: Mannual/Sctype/Azimuth/BoneMarrowMap/Caret etc, CellChat/SCENIC/GSEA and terms filtering, monocle3 etc; Python: Scanpy/ScVI/scVelo etc)
- Unique blend of biological/pharmaceutical/medical background with comprehensive understanding of scRNA-seq analyses
- Experimental design and optimization
- Presentation of complex findings to a wide array of audiences
Certification
Professional Certificate in Data Analysis for Genomics (HarvardX, Harvard T.H. Chan School of Public Health)
Timeline
Postdoctoral Researcher
University of Ottawa
08.2024 - Current
Professional Certificate in Data Analysis for Genomics (HarvardX, Harvard T.H. Chan School of Public Health)
08-2020
Clinical Research Internship
The Chinese University of Hong Kong
06.2017 - 06.2019
Ph.D. - Biomedical Sciences
The Chinese University of Hong Kong
05.2001 -
Master of Science - Biomedical Engineering
The Chinese University of Hong Kong
05.2001 -
Bachelor of Engineering - Biomedical Engineering
City University of Hong Kong
05.2001 -
Similar Profiles
Kelly Marleen SEBAGANJIKelly Marleen SEBAGANJI
Junior Media Relations & Communications Officer at University of OttawaJunior Media Relations & Communications Officer at University of Ottawa
Mikayla LongMikayla Long
Intake Specialist at University of OttawaIntake Specialist at University of Ottawa
Abdu-Rahman BarkhadAbdu-Rahman Barkhad
Mechanical Engineering Intern at University of OttawaMechanical Engineering Intern at University of Ottawa
Saloua El OuafiSaloua El Ouafi
Human Resources Manager at University of OttawaHuman Resources Manager at University of Ottawa
Jean Charles DOUHOTJean Charles DOUHOT
Conseiller Clientèle – Gestionnaire de comptes at ADVANS CÔTE D'IVOIREConseiller Clientèle – Gestionnaire de comptes at ADVANS CÔTE D'IVOIRE