Michelle Chan
Vancouver,BC
Summary
A highly motivated Associate Scientist with strong desire to learn, contribute and collaborate. Had 5 years of industrial experience focusing on protein purification and antibody characterization. Ability to work independently in a highly collaborative, fast-paced, team-oriented environment. Strong organizational skills with the ability to handle multiple projects simultaneously with high degree of accuracy. Reliable team player with excellent communication and problem-solving skills.
Overview
5
5
years of professional experience
1
1
Certification
Work History
Associate Research Scientist
AbCellera Biologics
01.2023 - Current
- Performed analytical assessment such as ce-SDS, DLS kD, DSC, icIEF, UPLC on lead drug candidates to assess product attributes
- Involved in downselection of manufacturable antibody as a potential drug candidate and in vivo studies
- Developed and optimized current analytical methods to adapt to new project needs (including bispecifics, VHH)
- Performed and involved in AC-SINS and BVP-ELISA method development to study non-specific protein-protein interaction
- Assisted with the development of forced degradation protocols (High pH, Low pH, oxidation, accelerated stability studies) to evaluate inherent properties of molecules
- Utilized advanced statistical techniques using ANOVA and t-test for data analysis, ensuring accurate interpretation of experimental outcomes
- Produced high quality data reports and figures using GraphPad Prism
- Effectively communicated findings and results to the team on a weekly basis
Research Technician
AbCellera Biologics
03.2020 - 12.2022
- Performed high throughout protein purification on 96-well plates using Liquid Handling robots (Hamilton)
- Conducted UV-Vis quantification, BLI, ce-SDS and endotoxin testing as part of antibody QC
- Understand the biophysical properties of molecules using DLS and nano-DSF
- Acted as a liaison in multiple projects to facilitate inter-teams communication
- Trained and onboarded new team members to ensure smooth integration into the company culture and workflows
- Achieved significant progress in research projects by collaborating closely with multidisciplinary teams of scientists, data scientists, and engineers to facilitate new technology integration
- Designed and optimized workflows to increase productivity and efficiency
- Moderated biweekly team meetings to encourage knowledge sharing
Student Researcher
Canada's Michael Smith Genome Sciences Centre
01.2019 - 12.2019
- Performed subculturing and microscopic techniques to monitor and visualize the growth of breast cancer cell lines in response to proteasome inhibitors
- Conducted western blot and immunoblotting to understand the correlation between autophagy-related proteins
- Executed proteasomal activity assay and siRNA knockdown to understand cellular proteasome function
- Performed crystal violet assay to quantify cell viabilities
- Optimized drug concentration for better characterization of protein levels
- Enhanced research quality by diligently reviewing and analyzing relevant literature sources
- Contributed to the publication of an academic paper by assisting with data collection and analysis
- Increased lab safety by maintaining a clean and organized workspace throughout the research process
Education
Bachelor of Science [Hons] - Molecular Biology And Biochemistry
Simon Fraser University
Burnaby, BC2019
Skills
- ELN (Benchling)
- SPSS & GraphPad Prism & R
- Microsoft Excel, Powerpoint, Word
Websites
Certification
Cally H, Gayathri S, Katharina R, Jing X, Kevin Y, Emily Y, Michelle C, Xiaoyan J, Sharon G. Puncta intended: connecting the dots between autophagy and cell stress networks [April, 2021]
References
Available upon request
Languages
English
Full Professional
Cantonese/Mandarin
Professional Working
Hobbies
- Baking
- Travelling
- Crocheting
Timeline
Associate Research Scientist
AbCellera Biologics
01.2023 - Current
Research Technician
AbCellera Biologics
03.2020 - 12.2022
Student Researcher
Canada's Michael Smith Genome Sciences Centre
01.2019 - 12.2019
Bachelor of Science [Hons] - Molecular Biology And Biochemistry
Simon Fraser University
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