Wenqi Yang (Mavis)
London,ON
Summary
A highly motivated Medical Bioinformatics student with a BSc in Basic Medical Science and a minor in Computer Science from Western University. Experienced in single-cell multiomic analysis, including transcriptomic and epigenomic integration, differential expression, and pathway enrichment using R. Skilled in scientific data visualization, research methodology, and managing large biological datasets. Cross-cultural competence with international academic experience; fluent in English and Chinese, with proven ability to translate and interpret Chinese scientific literature.
Overview
2
2
years of professional experience
Work History
Single-Cell Analysis of MPN Leukemic Progression
Western University
London, Canada
09.2024 - Current
- Analyzed single-cell RNA and ATAC data from hematopoietic stem/progenitor cells of 12 MPN patients (6 transformed, 6 untransformed)
- Conducted differential abundance testing using MiloR and pseudo-bulk differential expression analysis with DESeq2 across group, sex, and interaction terms
- Performed dimensionality reduction (PCA), and functional enrichment analysis using FGSEA with Hallmark and Reactome gene sets
- Generated summary reports, UMAP visualizations, heatmaps, and cell-type-specific DE profiles to identify transformation-associated pathways
Lab Volunteer
Dr. Poon's Lab
London, Canada
11.2023 - 05.2024
- Working on OpenRDP project (fixing simple code and answer questions on GitHub)
- Attending every week lab meeting and listening to each lab member's presentation.
Education
Bachelor of Science - Honor specialization in MBI; Minor in Computer Science
University of Western Ontario
London, Canada04-2025
High School Diploma -
Bell High School
Ottawa07.2020
Skills
- Single-cell multiomics: scRNA-seq and scATAC-seq analysis using Seurat, Signac, and MiloR
- Differential expression & abundance: Pseudo-bulk DE with DESeq2; DA analysis with MiloR
- Pathway enrichment: FGSEA on PCA loadings and DE gene sets (Hallmark, Reactome)
- Data visualization: UMAP, PCA, heatmaps, and beeswarm plots in R (ggplot2, pheatmap)
- Statistical modeling: Multi-factor designs, interaction terms, and quality control in DESeq2
- Data science tools: Proficient in R (dplyr, purrr, Matrix), basic SQL, and data reshaping
- Skilled in literature search and data extraction using Western Libraries and scientific databases
- Experienced in research methodology, protocol adherence, and managing large biological datasets
- Cross-cultural competence: international academic experience, fluent in English and Chinese, adept at translating and interpreting Chinese scientific literature
Timeline
Single-Cell Analysis of MPN Leukemic Progression
Western University
09.2024 - Current
Lab Volunteer
Dr. Poon's Lab
11.2023 - 05.2024
Bachelor of Science - Honor specialization in MBI; Minor in Computer Science
University of Western Ontario
High School Diploma -
Bell High School
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