Maitree Biswas
Richmond,BC
Summary
Meticulous and passionate research professional with 10+ years of experience in Biology research in both academy and industry set-up. Skilled in different areas of Biology including Biochemistry, Molecular Biology, Cell Biology and Structural Biology, with conceptualization, experiment design, analysis and data representation. Hardworking and intense about advancement in Biology research with effective problem solving and leadership skills.
Overview
16
16
years of professional experience
1
1
Certification
Work History
Scientist
Primary Peptides Inc
09.2022 - Current
- Lead the in-vitro screening for bi-functional degrader peptides against neurological disorders
- Investigated >15 degrader peptides in cells against clinically proven targets
- Evaluated and implemented new technologies and laboratory techniques to improve quality and robustness of sample analysis.
- Read literature related to scientific area of research, consulted with researchers to analyze problems, recommend technology-based solutions and determine solution strategies.
Research Associate
Vancouver Prostate Centre
01.2021 - 08.2022
- Expressed and purified recombinant prostate cancer specific receptors and accessed their quality and functionality
- Led the in vitro characterization of biomolecular condensates formed by the androgen receptor
- Requested or acquired equipment or supplies necessary for projects.
- Actively involved in equipment purchase for the Gobind Khorana Protein Engineering Core at VPC
- Studied the effect of different steroids on patient derived mutants of the androgen receptor (contractual work with privately held pharma company)
- Interpreted data analysis results to draw inferences and conclusions.
Postdoctoral Fellow
The University of British Columbia
01.2018 - 12.2019
- Expressed and purified the recombinant human HCN channels (HCN1, 2 and 4) for structural characterization by cryo-EM
- Prepared different disease mutants of the HCN1 and HCN2 channels and checked their functionality by electrophysiology
- Troubleshot and developed experimental facility to deal the electron microscopy sample preparation facility in the electrophysiology lab
Postdoctoral Fellow
The University of British Columbia
05.2015 - 12.2017
- Standardized the expression and purification of recombinant human lipid metabolism enzymes ACC1 and ACC2
- Studied the enzyme activity of the purified protein
- Involved in the characterization of S. cerevisiae autophagy protein Atg11 and its interaction with other proteins for autophagosome formation
- Conducted in-depth research on biochemical, structural and functional data to apply to fellowship and advance understanding.
Graduate Research Student
St. Xavier's College, Kolkata, India
01.2010 - 03.2015
- Performed experiments and conducted research to study structural insight of Vibrio cholerae chemotaxis proteins.
- Learned new laboratory techniques and applied expertise in carrying out enhanced experiments, data acquisition, analysis and report preparation.
- Performed accurate quantitative and qualitative analysis of collected data, prepare manuscript and publish findings.
Research Scholar
Indian Institute of Science Education and Research
11.2008 - 12.2009
- Expressed and purified miligrams amount of cyanobacterial nuclease from E
- Coli culture
- Involved in instrument purchase and established the set-up for a protein biochemistry lab
Visiting Lecturer
Bidhannagar College
08.2007 - 10.2008
- Taught general Microbiology and fermentation to the M.Sc
- Students
- Provided practical training to the M.Sc
- And B.Sc
- Students on general Microbiology techniques
Education
Ph.D - Biophysics, Molecular Biology And Bioinformatics
University of Calcutta
2015
M.Sc. - Marine Biotechnology
Goa University
2007
B.Sc. - Microbiology (Major), Chemistry And Mathematics
University of Calcutta
2005
Skills
- Molecular Biology and Protein Expression: General molecular biology procedures including PCR, cloning, mutagenesis Expression systems – E coli, Yeast, Insect and Mammalian cells
- Cell Biology: HEK293, CHO, LNCaP, PC3, MRC5, MCF7, DU145, TSA and stable cell line generation
- Protein purification techniques: AKTA based Affinity, Ion-exchange and Size exclusion chromatography
- Protein analysis and activity measurement: Western Blot, Peptide Assays, ELISA, pull-down, luciferase assays
- Biophysical techniques: ITC (Protein-ligand interaction), SEC-MALS, DLS, AUC and Negative stain EM (Macromolecular size and size distribution measurement)
- Microscopy: Confocal, Fluorescence and Electron microscope
- Protein Engineering: Multiple sequence alignment, Structure prediction, Homology modeling
- Structural biology, molecular modelling and Molecular visualization software
- Good Laboratory Practice (GLP), Laboratory Equipment Functions and Instructional Strategies
Certification
1. Chakraborty S, Agarwal S, Dey S, Biswas M, Ghosh B, Dasgupta J. FEBS Letters (2023). Accepted
2. Zhang F, Biswas M, Massah S, Lee J, Lingadahalli S, Wong S, Wells C, Foo J, Khan N, Morin H, Saxena N, Kung SHY, Sun B, Parra Nuñez AK, Sanchez C, Chan N, Ung L, Altıntaş UB, Bui JM, Wang Y, Fazli L, Oo HZ, Rennie PS, Lack NA, Cherkasov A, Gleave ME, Gsponer J, Lallous N. Nucleic Acids Res (2023); 51(1): 99-116.
3. Chakraborty S, Biswas M, Dey S, Agarwal S, Chakrabortty T, Ghosh B, Dasgupta J. J Biol Chem (2020); 295(50): 16960–16974.
4. Agarwal S, Dey S, Ghosh B, Biswas M, Dasgupta J. Biochim Biophys Acta Proteins Proteom (2019); 1867(2):140-151.
5. Agarwal S, Dey S, Ghosh B, Biswas M, Dasgupta J. Sci Rep. 2017; 7:42812.
6. Nanji T, Liu X, Chew LH, Li FK, Biswas M, Yu ZQ, Lu S, Dong MQ, Du LL, Klionsky DJ, Yip CK. Autophagy (2017); 13(12):2018-2027.
7. Agarwal S, Biswas M, Dasgupta J. Acta Crystallogr Sect F Struct Biol Commun (2015); 71(Pt 4):401-4.
8. Dey S, Biswas M, Sen U, Dasgupta J. J Biol Chem (2015); 290(14):8734-47.
9. Biswas M, Dey S, Khamrui S, Sen U, Dasgupta J. PLoS One (2013); 8(9): e73923.
10. Biswas M, Khamrui S, Sen U, Dasgupta J. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011); 67(Pt 12):1645-8.
11. Khamrui S, Biswas M, Sen U, Dasgupta J. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010); 66(Pt 8):944-7.
Additional Information
- Recipient of the award of Senior Research Fellowship from Indian Council of Medical Research (ICMR), 2013.
- Recipient of the International Union of Crystallography (IUCr) Travel Grant Award to attend the conference BSR 2013 at Hamburg, Germany.
- Qualified in the National Entrance Examination for M.Sc. in Biotechnology conducted by JNU, New Delhi and awarded National Scholarship sponsored by Department of Biotechnology (DBT), India, in 2005-2007.
Timeline
Scientist
Primary Peptides Inc
09.2022 - Current
Research Associate
Vancouver Prostate Centre
01.2021 - 08.2022
Postdoctoral Fellow
The University of British Columbia
01.2018 - 12.2019
Postdoctoral Fellow
The University of British Columbia
05.2015 - 12.2017
Graduate Research Student
St. Xavier's College, Kolkata, India
01.2010 - 03.2015
Research Scholar
Indian Institute of Science Education and Research
11.2008 - 12.2009
Visiting Lecturer
Bidhannagar College
08.2007 - 10.2008
Ph.D - Biophysics, Molecular Biology And Bioinformatics
University of Calcutta
M.Sc. - Marine Biotechnology
Goa University
B.Sc. - Microbiology (Major), Chemistry And Mathematics
University of Calcutta
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