Linda Suzanne DAVID

Versatile, intelligent and systematic Research Associate with extensive record of accomplishment as data reviewer, recordkeeper, and project coordinator. Hardworking and resourceful team player proficient in and experienced in the field. History of going above and beyond to achieve notable results.

• Huntington Study Group, Huston, 2018, In vitro validation of antibody-based therapy to neutralize mutant hutingtin protein., Siddu A
• David L.S, Oskar S, Stefan B, Queslati A, Cicchetti F.
• 18th Annual Huntington's Disease Therapeutics Conference- CHDI, Palm Springs, 2018, Inhibition of mutated HTT transmission by antibody interference., Bartl S, Oueslati A, Southwell A.L, Parth M, Salhat N, Siddu A, Burkert M, Mairhofer A, Pankevyc H, David L.S, Villanueva E.B, Xie Y, Dal Cengio L, Ko S, Hayden M.R, Galabova G, Ciccheti F, Smrzka O.W.
• Society for Neuroscience, San Diego, 2009, The extracellular matrix glycoprotein tenascin-R affects adult but not developmental neurogenesis in the olfactory bulb., David L.S
• And Saghatelyan, A
• Development. Association Canadienne des Neurosciences CAN, Quebec City, 2011, TNR affects adult neurogenesis: A functional analysis of the implications of adult neurogenesis to the olfactory bulb., David L.S
• Schachner M, Saghatelyan, A.
• Association Canadienne des Neurosciences CAN, Montreal, 2008, The extracellular matrix glycoprotein tenascin-R affects adult but not developmental neurogenesis in the olfactory bulb., David L.S
• And Saghatelyan, A.

• Raptor/Horizon Pharma, Project leader for assessing the therapeutic effects of Cysteamine in mouse, ex vivo and in vitro models of neurodegenerative diseases.
• AFFiRiS (Vienna, Austria), Planning experiments and supervising a PhD student in an in vitro project tailored to validate the ability of a monoclonal anti-mutant huntingtin antibody in binding and neutralizing of extracellular forms of the protein, thereby preventing uptake and infection of healthy cells.
• Dr. Claus Pietrzik (Institute of pathobiochemistry, Universitätsmedizin Mainz), Team member in project designed to determining the interactions between mutant huntingtin and the low-density lipoprotein receptor-related r protein-1 (LRP1), especially the transport of mutant huntingtin by this receptor.
• Dr. Thomas Durcan (The Montreal Neurological Institute, McGill University), Responsible for designing and conducting experiments to test the therapeutic nature of cysteamine as a neurorestorative agent on dopaminergic neurons derived from parkinsonian and control human subject induced pluripotent stem cells (iPSCs).

• 7th edition of the NeuroSymposium, Montreal, 2022, Served as a judge for poster and oral sessions on Therapy development and clinical neuroscience and system neuroscience presented by postdoctoral fellows and PhD students.
• 5th and 6th virtual edition of the NeuroSymposium, Montreal, 2020 & 2021, Served as a judge for poster sessions on Therapy development and clinical neuroscience and system neuroscience presented by PhD students.
• 4th edition of the NeuroSymposium, Montreal, 2019, Served as a judge for poster sessions on Therapy development and clinical neuroscience and system neuroscience presented by PhD students.
• 3rd edition of the NeuroSymposium, Montreal, 2018, Served as a judge for poster sessions on Therapy development and clinical neuroscience and system neuroscience presented by PhD students.
• 7th edition of the Frontiers in Neurophotonics, Centre de recherche CERVO, Université Laval, 2014, Tutoring
• Canadian Science Policy Center (CSPC), 2022-present, Volunteering as part of the awards committee

• 2011, Prix d’excellence (Université Laval), 250 CAD, Best PhD platform presentation, Journée de la recherche en Neurosciences, Université Laval, Québec, Canada
• 2009-2010, Neuroscience Thematic Research Centre (CTRN), 12000 CAD, One-year scholarship to best PhD candidate
• 2008, Prix d’excellence (CTRN), 500 CAD, Best MSc platform presentation, Journée de la recherche en Neurosciences, Université Laval Québec, Canada
• 2006, Ranked 1st in MSc Biotechnology, St Joseph’s College, Tamil Nadu, India, The ranking was done amongst all students pursuing a MSc in biotechnology in St Joseph’s College
• 2004, Ranked 9th in BSc Microbiology, Bharathidasan University, Tamil Nadu, India, The ranking was done amongst all students pursuing a BSc in microbiology amongst all colleges affiliated to the Bharathidasan University

• 01/2024, Present, Research associate III, University of Ottawa, Roger Guindon Hall, Ottawa, Ontario, Canada, Dr. Luca Pellegrini, Training all incoming students and postdoctoral fellows in fundamental science. Making sure the day to day running of lab moves smoothly.
• 11/2020, Present, Research associate III, University of Ottawa, Roger Guindon Hall, Ottawa, Ontario, Canada, Dr. Katalin Toth, Training all incoming students and postdoctoral fellows in electrophysiology, immunofluorescence, microscopy and analyses. Making sure the day to day running of lab moves smoothly. Projects in understanding connections between the entorhinal cortex and the hippocampus.
• 06/2017, 11/2020, Project manager, Université Laval, Centre de recherche du CHU de Québec, Québec, Québec, Canada, Dr. Francesca Cicchetti, Actively participated in the design and setup of a phase II trial testing novel disease-modifying therapeutic in early Parkinson’s disease patients. MSc and PhD student supervision (n=4). Grant/paper writing and reviewing. Active participation in organizing and presenting in open days for Parkinson’s and Huntington’s patients.
• 06/2015, 06/2017, Post-doctoral fellowship in Neuroscience, Université Laval, Centre de recherche du CHU de Québec, Québec, Québec, Canada, Dr. Francesca Cicchetti, Cysteamine: a novel disease-modifying treatment for Parkinson’s Disease.
• 12/2013, 05/2015, Post-doctoral fellowship in Biochemistry, Université Laval, Centre de recherche CERVO, Québec, Québec, Canada, Dr. Lisa Topolnik, Cell-type specific disinhibition of CA1 hippocampal interneurons in chronic temporal lobe epilepsy.
• 08/2009, 12/2013, PhD in Neurobiology, Université Laval, Centre de recherche CERVO, Québec, Québec, Canada, Dr. Armen Saghatelyan, Adult Neurogenesis: regulation, heterogeneity and functions of adult born interneurons in the olfactory bulb.
• 01/2007, 08/2009, MSc in Neurobiology, Université Laval, Centre de recherche CERVO, Québec, Québec, Canada, Dr. Armen Saghatelyan, The extracellular matrix glycoprotein Tenascin-R and its role in adult neurogenesis.
• 06/2006, 12/2006, Lecturer, St. Joseph's college, Trichy, Tamil Nadu, India, Biotechnology
• 06/2004, 04/2006, MSc in Biotechnology, Bharathidasan University, St. Joseph’s college, Tamil Nadu, India, Dr. Gabriel Melcias, Cloning and expressing the coat proteins of the banana streak virus in native bananas.
• 06/2001, 04/2004, BSc in Microbiology, Bharathidasan University, Tamil Nadu, India

• English, native
• French, professional working

• Siddu A
• David L.S, Lauinger N, Chen X, St-Pierre M, Alpaugh M, Durcan T, Cicchetti F., Beneficial effects of Cysteamine in Thy1-αSyn mice and induced pluripotent stem cells derived from patients with a SNCA gene triplication: implications for the treatment of Parkinson's disease., Neurobiol. of Dis., 2020, 145, 105042, 10.1016/j.nbd.2020.105042
• Bartl S, Southwell A.L, Oueslati A, Parth M, Salhat N, Siddu A, Maxan A, Burkert M, Mairhofer A, Pankevyc H, David L.S, Villanueva E.B, Xie Y, Dal Cengio L, Ko S, Galabova G, Hayden M.R, Ciccheti F, Smrzka O.W., Inhibiting cellular uptake of mutant huntingtin using a monocolonal antibody: Implications for the treatment of Huntington’s disease., Neurobiol. of Dis., 2020, 141, 104943, 10.1016/j.nbd.2020.104943
• Denis H.L
• David L.S
• Cicchetti F., Antibody-based therapies for Huntington’s disease: current status and future directions., Neurobiol. of Dis., 2019, 132, 104569, 10.1016/j.nbd.2019.104569
• Cicchetti F, David L.S, Siddu A, Helena D., Cysteamine as a novel disease-modifying compound: More than a decade of research supporting clinical trial in Parkinson’s disease., Neurobiol. of Dis., 2019, 130, 104530, 10.1016/j.nbd.2019.104530
• Masnata M, Sciacca G, Maxan A, Denis H, Lauruol F, David L.S, Saint-Pierre M, Kordower J, Bousset L, Melki R, Alpaugh M, Cicchetti F., Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms., Acta Neuropathol., 2019, 137, 6, 981-1001, 10.1007/s00401-019-01973-6
• Magnin E, Francavilla R, Amalyan S, Gervais E, David L.S, Luo X, Topolnik L., Input-specific synaptic location and function of the alpha5 GABAA receptor subunit in the mouse CA1 hippocampal neurons., J. Neurosci., 2019, 39, 5, 788-801, 10.1523/JNEUROSCI.0567-18.2018
• David L.S, Saint-Pierre M, Lamontagne-Proulx J, Cicchetti F., The effects of cysteamine in a mouse model of levodopa-induced dyskinesias., Neurosci. Lett., 2018, 662, 395-401, 10.1016/j.neulet.2017.10.062
• David L.S and Topolnik L., Target-specific alterations in the VIP inhibitory drive to hippocampal GABAergic cells after status epilepticus., Exp. Neurol., 2017, 292, 102-112, 10.1016/j.expneurol.2017.03.007
• Malvaut S, Gribaudo S, Hardy D, David L.S, Daroles L, Labrecque S, Lebel-Cormier M.A, Chaker Z, Cote D, De Koninck P, Holzenberger M, Trembleau A, Caille I, Saghatelyan A., CaMKII expression defines two functionally distinct populations of granule cells involved in different types of odour behaviour., Curr. Biol., 2017, 27, 21, 3315-3329, 10.1016/j.cub.2017.09.058
• Tyan L, Chamberland S, Magnin E, Camiré O, Francavilla R, David L.S, Deisseroth K, Topolnik L., Dendritic inhibition provided by interneuron-specific cells controls the firing rate and timing of the hippocampal feedback inhibitory circuitry., J. Neurosci., 2014, 34, 13, 4534-4547, 10.1523/JNEUROSCI.3813-13.2014
• David L.S, Schachner M, Saghatelyan A., The extracellular matrix glycoprotein tenascin-R affects adult but not developmental neurogenesis in the olfactory bulb., J. Neurosci., 2013, 33, 25, 10324-39, 10.1523/JNEUROSCI.5728-12.2013
• Bastien-Dionne P.O
• Parent A, Saghatelyan A., Role of sensory activity on chemospecific populations of interneurons in the adult olfactory bulb., J. Comp. Neurol., 2010, 518, 10, 1847-61, 10.1002/cne.22307

• Huntington Society Quebec open day, 2018, Actively participated in the organization of the open day. Presented on various aspects of Huntington’s disease and interacted with huntingtonian patients and families.
• Parkinson Society Quebec open day, 2018, Actively participated in the organization of the open day. Presented on various aspects of Parkinson’s disease and interacted with parkinsonian patients and families.