Lei Zhang

A highly motivated and collaborative biomedical scientist with over 10 years of hands-on research experience in virology and stem cell fields. An innovative yet methodical thinker with strong expertise in in vitro and preclinical assay development for function evaluation, and molecular mechanism investigation and ability to integrate scientific knowledge into translational application. A bold and enthusiastic explorer with meticulous mind.

• Research and experiments
• Research implementation
• Analytical skills
• Adaptable to fast-paced team environment
• Teamwork
• Multitasking abilities
• Outsource management
• Training and mentoring
• Cultural awareness
• Good organizational, record keeping and communication skills
• Microsoft Suite and various analysis softwares proficiency

Patent:

1.  Title: Synthetic adenoviruses targeting bone tissue and uses thereof. Inventors: Clodagh O'Shea, Colin Powers, Lei Zhang US20190314525, Pending

2.  Title: Synthetic adenoviruses with tropism to damaged tissue for use in promoting wound repair and tissue regeneration. Inventors: Clodagh O'Shea, Colin Powers, Lei Zhang

US20180221423, Pending

3.  Title: Tumor-targeting synthetic adenoviruses and uses thereof. Inventors: Clodagh O'Shea, Colin Powers, Lei Zhang US20190314523, Pending

Publications:

1.  Yao, J. *, Zhang, L. *, Hu, L., Guo, B., Hu, X., Borjigin, U., Wei, Z., Chen, Y., Lv, M., Lau, J.T., et al. (2016). Tumorigenic potential is restored during differentiation in fusion-reprogrammed cancer cells. Cell Death Dis 7, e2314. (*Co-first authors contributed equallyto this work)

2.  Xiao Hu*,Lei Zhang*,Shi-Qing Mao*,Zheng Li, Jiekai Chen, Run-Rui

Zhang, Hai-Ping Wu, Juan Gao, Fan Guo, Wei Liu, Yufei Xu, Yujiang Geno Shi, Duanqing Pei, and Guo-Liang Xu. (2014) Tet and TDGMediate DNA Demethylation Essential for Somatic Cell Reprogramming. Cell Stem Cell,14, 1-11. (* Co-first authors contributed equally to this work)

3.  Chen, J.K.*, Guo, L.*, Zhang, L.*, Wu, H.Y., Yang, J.Q., Liu, H., Wang, X.S., Hu, X., Gu, T.P., Zhou, Z.W., et al. (2013). Vitamin C modulates Tet1 function during somatic cell reprogramming. Nat Genet, 45, 1504-1509. (*Co-first authors contributed equally to thiswork)

4.  Wang, Y., Chen, J., Hu, J.L., Wei, X.X., Qin, D., Gao, J., Zhang, L., Jiang, J., Li, J.S., Liu, J., et al. (2011). Reprogramming of mouse and human somatic cells by high-performance engineered factors. EMBO Reports 12, 373-378.

5.  Yao, J.Y., Zhang, L., Zhang, X., He, Z.Y., Ma, Y., Hui, L.J., Wang, X., and Hu, Y.P. (2010). H3K27 trimethylation is an early epigeneticevent of p16INK4a silencing for regaining tumorigenesis in fusion reprogrammed hepatoma cells. The Journal of Biological Chemistry 285,18828- 18837.

6.  Zhang, L. (2009). Epigenetic mechanism in cell reprogramming. Chinese Bulletin of Life Science 21, 614-619.

References can be provided upon request