Krishraj Jadeja

Coming with an experience from various fields as a young individual as in food market then growing out towards the health sector. I am a hardworking talent which offers maximum efficiency in workspace. Diligent College Student focused in Health Care and dedication to prompt project completion and continual adaptation. Team-oriented collaborator with reliability and focus on equitable task distribution through group projects and motivation to accomplish mutually held goals. Looking forward to developing my abilities and knowledge.

My role was to apply gene editing tool and its affect on the Microbiome. I chose CRISPR as a great potential for this. The CRISPR/Cas9 system has evolved into an accurate gene-editing tool with uses well beyond its initial purpose, such as studying the microbiome and maybe curing human health conditions. The discovery of unique DNA sequences that demonstrated the protein's role in bacterial defence set the groundwork for CRISPR's current use as a gene editing tool. In essence, The CRISPR/Cas9 mechanism targets certain DNA sequences to function. The process is initiated by a guide RNA (gRNA) that is intended to bind to a complementary DNA sequence. The Cas9 enzyme functions as molecular scissors, detecting the target and cutting the DNA at the exact location. This change might result in the addition of a new DNA sequence or the removal of a segment. These precise modifications have the power to correct genetic mutations, regulate gene expression levels, or even alter a single base pair. Gene Editing and CRISPR Mechanisms in Microbiome Research The human microbiome, which is made up of the billions of microorganisms that inhabit our bodies, is essential to overall health. A variety of diseases, like obesity, mental health conditions, and inflammatory disorders, are associated with dysbiosis, or imbalances in this ecosystem.