Ketul Patel
Calgary,Canada
Summary
Skilled organic and medicinal chemist, having 9+ years of experience in research; currently working as a Mitacs Industrial Postdoctoral Scientist at Zymedyne Therapeutics/University of Calgary. Also, worked as a Senior Scientist in the synthesis division of drug discovery-based Aten Porus Lifesciences, India. Expertise in multi-step synthesis, Synthetic target design, Drug discovery (New project design), SAR studies and methodology development. Experienced in small molecules-based Hit to Lead to Optimized Lead Identification in different therapeutic disease areas mainly in immuno-oncology, neurotherapeutics and metabolic disorders.
Overview
9
9
years of professional experience
Work History
Mitacs Industrial Postdoctoral Scientist
Zymedyne Therapeutics/University of Calgary
Calgary, Canada
04.2022 - Current
- Developed a small molecule inhibitor of T-type calcium channels for the non-opioid treatment of chronic neuropathic pain. Co-inventor of small molecule inhibitors for which a provisional patent has been filed.
- Interpret and analyze data, prepare and review study reports/presentations, communicate project progress to internal and external stakeholders.
- Played an instrumental role in grant writing, contributing to the successful acquisition of two grants totaling C$180,000 for drug discovery projects. Assisted in the preparation and submission of grant proposals, effectively conveying the significance and potential impact of the projects to funding organizations.
Postdoctoral Research Scientist
University of Calgary, Derksen Research Group
Calgary, Canada
12.2020 - 03.2022
- Developed heterobifunctional molecules for Proteolysis Targeting Chimeras (PROTACs), a novel approach for targeted protein degradation in the treatment of Multiple Myeloma (MM) cancer; Also demonstrated a methodology to the C-3 functionalization of pyrazole, a medicinally useful heterocycle.
- Provided mentorship to junior masters/PhD students.
- Demonstrated strong time and project management skills, ensuring strategic completion of tasks within established timelines, effectively coordinating resources and prioritizing activities to meet deadlines.
Senior Scientist
Aten Porus Lifesciences
Bengaluru, India
03.2018 - 03.2020
- Developed and implemented new synthetic pathways, route-optimization strategies, molecular docking techniques (utilizing Schrödinger and Cresset software), and conducted virtual screening and medicinal chemistry-based approaches to support internal and collaborative drug discovery and
development initiatives. - Successfully executed the synthesis and characterization of small molecules, intermediates, and building blocks, both individually and in library formats, through multi-step synthesis processes (7-12 steps) at varying scales (mg to gm scales).
- Actively contributed as a key member of a cross-functional team, effectively communicating drug discovery findings to external collaborators and contract research organizations (CROs)
- Demonstrated exceptional project management skills, leading two drug discovery projects from hit identification to lead optimization, encompassing in vitro parameter optimization and in vivo PK/efficacy data evaluation.
- Recognized as a co-inventor of two patents, including a promising small molecule inhibitor (ENPP1 inhibitor), currently in advanced stages for the filing of an Investigational New Drug (IND) application.
- Developed clear and structured research plans, delivering regular project updates to internal stakeholders, key opinion leaders and scientific advisory board.
- Supervised a team of junior scientists, providing guidance, mentoring, and fostering a collaborative work environment to enhance productivity and achieve team objectives.
PhD Research Scholar
National Institute of Pharmaceutical Education and Research (NIPER))
S.A.S. Nagar, India
07.2014 - 12.2017
- Developed decarboxylative acylation chemistry using α-oxocarboxylic acids, specializing in C-C and C-N bond formation, advancing modern organic synthesis for nitrogen heterocycles and active pharmaceutical ingredients (APIs).
- Demonstrated effective communication skills, presented scientific findings at conferences and symposiums, and demonstrated a proficiency scientific writing for peer-reviewed journals, contributing to knowledge sharing and the scientific community.
- Exhibited strong leadership and interpersonal communication skills as a mentor and trainer for six master's students, guiding them in their dissertation research projects to successful completion.
Education
Ph.D. - Pharmaceutical Technology (Process Chemistry)
NIPER-SAS Nagar
Mohali, Inida12.2017
Master of Technology (M.Tech) - Pharmaceutical Technology (Process Chemistry)
NIPER-SAS Nagar
Mohali, India06.2014
Bachelor of Pharmaceutical Sciences (B.Pharm) -
L. M. College of Pharmcay
Ahmedabad, India05.2012
Skills
Synthesis: Multi-step synthesis; Methodology development; mg to gm scale synthesis; Synthetic route design; Modern organic synthesis
Computational: Molecular docking by Maestro-Schrodinger and Cresset
software; Structure-based drug discovery (SBDD); Ligand-based drug discovery (LBDD); scaffold hopping; R group exploration; predicting drug-likeness properties; ADMET prediction
Purification Techniques: Well‐versed with Flash chromatography, column chromatography, HPLC, LC-MS, GC-MS, distillation, recrystallization
Structural elucidation: Well‐versed with structural elucidation using UV-VIS spectrometer, FTIR, NMR (400 and 600 MHz) & Mass spectroscopy (LCMS/GCMS/MALDI-TOF-TOF/HRMS)
Scientific Writing: Expertise in manuscript writing for peer reviewed journals; Assisted in grant writing; Awarded C$ 180,000 funding in collaboration with industry partner for new drug discovery
Awards & Honours
PorusPorusZymedyneZymedyne
- “Mitacs Industrial Postdoctoral Fellowship" for the year 2022-23 to pursue research in Canada; Another grant was awarded for the year 2023-2025.
- “Excellent Research Contribution Award" for the year 2016-17 in JKL research group.
- Senior Research Fellow under SERB-DST project (2016-2017).
- Junior Research Fellow under SERB-DST project (2014-2016).
- Awarded NIPER fellowship for M. Tech. (Pharm.) 2012-2014.
Conference Presentation
Presented at 21st International Conference on Organic Synthesis (ICOS 21), IIT Mumbai, 2016, 21st CRSI National Symposium in Chemistry, CSIR-IICT, Hyderabad, India, 2017.
Patent
- Patel, K.; Zamponi, G.; Derksen, D. “Tetrahydroquinoline Derivatives for Inhibiting Cav3.2-Usp5 Interactions” US Provisional Patent filed, Feb. 2023
- Kulkarni, A.; Goyal, S.; Khurana, P.; Patel, K.; Cyriac, R.; Kataru, B. A. S.; Gangar, M.; Mukherjee, A. “2-Amino-S6-Substituted Thiopurine Compounds as Inhibitors of The ENPP1 Protein” WO/2021/053507; US 2023/0002387 A1
- Kulkarni, A.; Goyal, S.; Dolas, A.; Raikar, S.; Khurana, P.; Patel, K.; Nagare, Y.; Raykar, D.; Agrawal, A. “Compounds and Methods for the Treatment of Non‐Alcoholic Steatohepatitis” WO/2019/111225
Publications
Research Papers: 11; Citations: 220; h-index 7
https://scholar.google.co.in/citations?user=Var3rb4AAAAJ&hl=en
- Gangar, M.; Goyal, S.; Raykar, D. B.; Khurana, P.; Martis, A. M.; Goswami, A.; Ghosal, I.; Patel, K. V.; Nagare, Y.; Raikar, S.; Mukherjee, A.; Cyriac, R.; Paquin, J-F; Kulkarni, A. “Design, synthesis and biological evaluation studies of novel small molecule ENPP1 inhibitors for cancer immunotherapy” Bioorg. Chem. 2022, 119, 105549.
- Patel, K. V.*; O’Sullivan, L.*; Rowley, B. C.*; Brownsey, D. K.; Gorobets, E.; Gelfand, B. S.; van Humbeck, J. F.; Derksen, D. J. “Regioselective Synthesis of C3-Hydroxyarylated Pyrazoles” J. Org. Chem. 2022, 87, 846–854 *Contributed equally to work.
- Patel, K. V*.; Goyal, S*.; Nagare, Y.; Raykar, D. B.; Raikar, S. S.; Dolas, A.; Khurana, P.; Cyriac, R.; Sarak, S.; Gangar, M.; Agrawal, A.; Kulkarni, A. “Identification and Structure-Activity Relationship studies of small Molecule Inhibitors of the Human Cathepsin D” Bioorg. Med. Chem. 2021, 29, 115879. *contributed equally to work.
- Laha, J. K.; Pande, S.; Tomar, M.; Patel, K. V. “Possible competitive modes of decarboxylation in the annulation reactions of ortho-substituted anilines and arylglyoxylates” Org. Biomol. Chem. 2021, 19, 845-853.
- Laha, J. K.; Patel, K. V.; Pande, S.; Vashisht, V.; Solanke G.; Saima “Scope of Regioselective Suzuki Reactions in the Synthesis of Arylpyridines and Benzylpyridines and their Subsequent Intramolecular Cyclizations to Azafluorenes and Azafluorenones” New J. Chem. 2018, 42, 16069-16074.
- Laha, J. K.; Patel, K. V.; Tummalapalli, K. S. S. “Palladium-Catalyzed Serendipitous Synthesis of Arylglyoxylic Amides from Arylglyoxylates and N,N-Dialkylamides in the Presence of Halopyridines” ACS Omega 2018, 3, 8787-8793.
- Laha, J. K.; Patel, K. V.; Sharma S. “Palladium-Catalyzed Decarboxylative ortho-Acylation of Tertiary Benzamides with Arylglyoxylic Acids” ACS Omega 2017, 2, 3806-3815.
- Laha, J. K.; Patel, K. V.; Dubey G.; Jethava K. P. “Intramolecular Minisci Acylation under Silver-Free Neutral Conditions for the Synthesis of Azafluorenones and Fluorenones” Org. Biomol. Chem. 2017, 15, 2199-2210.
- Laha, J. K.; Jethava, K. P.; Patel, S.: Patel, K. V. “Intramolecular Acylation of Unactivated Pyridines or Arenes via Multiple C–H Functionalizations: Synthesis of All Four Azafluorenones and Fluorenones” J. Org. Chem. 2017, 82, 76-85.
- Laha, J. K.; Patel, K. V.; Tummalapalli, K. S. S.; Dayal, N. “Formation of Amides, their Intramolecular Reactions for the Synthesis of N-heterocycles, and Preparation of a Marketed Drug, Sildenafil: a Comprehensive Coverage” Chem. Commun. 2016, 52, 10245-10248.
- Laha, J. K.; Dayal, N.; Jain, R.; Patel, K. ''Palladium-Catalyzed Regiocontrolled Domino Synthesis of N-Sulfonyl Dihydrophenanthridines and Dihydrodibenzo[c,e]azepines: Control over the Formation of Biaryl Sultams in the Intramolecular Direct Arylation'' J. Org. Chem. 2014, 79, 10899-10907.
References
Dr. Darren Derksen - Associate Professor
Department of Chemistry | University of Calgary
Email: dderksen@ucalgary.ca
Dr. Jeffrey Van Humbeck - Assistant Professor
Department of Chemistry | University of Calgary
Email: jeffrey.vanhumbec1@ucalgary.ca
Dr. Aditya Kulkarni - Chief Scientific Officer
Avammune Therapeutics, USA
Aten Porus Lifesciences, India
Email: aditya@atenporus.com
Timeline
Mitacs Industrial Postdoctoral Scientist
Zymedyne Therapeutics/University of Calgary
04.2022 - Current
Postdoctoral Research Scientist
University of Calgary, Derksen Research Group
12.2020 - 03.2022
Senior Scientist
Aten Porus Lifesciences
03.2018 - 03.2020
PhD Research Scholar
National Institute of Pharmaceutical Education and Research (NIPER))
07.2014 - 12.2017
Ph.D. - Pharmaceutical Technology (Process Chemistry)
NIPER-SAS Nagar
Master of Technology (M.Tech) - Pharmaceutical Technology (Process Chemistry)
NIPER-SAS Nagar
Bachelor of Pharmaceutical Sciences (B.Pharm) -
L. M. College of Pharmcay
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