JEAN-YVES SANCÉAU

Experienced and passionate scientific researcher with high creativity, specialist in the design and synthesis of new molecules of industrial interest. Offering 20-year track record of delivering projects within timeline and budget constraints.

• I participated in the preclinical phase launch of several molecules (4) for oncology, including radio-labeled material.
• I was involved in the creation and development of a new academic CRO service (Organic Synthesis Service of the CRCHU de Québec) in which I helped several life science researchers.
• Among others, I collaborated in the development of a new phytochemical agent marketed under the Weed Out Ultra® brand. I invented new synthetic analogues of omega-3 acids with amazing biological properties that have attracted several investments resulting in a turnover increase of the Service.
• 8 patents, 16 publications.

• 1. Preparation of resolvin-triazolo analogs and uses thereof July 2024, WO2024
• 2. Preparation of resolvin analogs as anti-inflammatory agents and antioxidants August 2023 WO2023137554.
• 3. Derivatives of the protectin 10S, 17S-diHDA(PDX) and use thereof as antiviral, anti-inflammatory, and anti-diabetic agents

      December 2022 WO2022266763.

• 4. Novel inhibitors of 17b-HSD7 and uses thereof December 2022 WO2022261774.
• 5.Total syntheses of specialized pro-resolving mediators (SPMs), structural isomers and structural analogs February 2022 WO2022020963.
• 6. Compounds for the inhibition of herpes viruses January 2014 US 8791299 B2 20140729.
• 7. Preparation of 17α-substituted steroids as systemic antiandrogens and selective androgen receptor modulators January 2008

      US WO2008124922.

• 8. Preparation of helix 12 directed steroids for the treatment of androgen related diseases January 2005 CA WO 2005066194 A1 20050721.
• 9: Preparation of inhibitors of type 5 and type 3 17β-hydroxysteroid dehydrogenase January 1999 CA WO 9946279 A2 19990916.

• 1. Development of New Resolvin D1 Analogues: Acellular and Computational Approaches To Study Their Antioxidant Activities Zahra Kariminezhad, Candice Dulong, Mahdi Rahimi, Patricia Rondon, Julio Fernandes, René Maltais, Jean-Yves Sancéau, Donald Poirier, Hassan Fahmi, Mohamed Benderdour, Antioxydants, 2024
• 2. 14C-radiolabeling of a new steroidal antiandrogen with a C-18 angular methyl extension, Jean-Yves Sancéau, Journal of Labelled Compounds and Radiopharmaceuticals 2023,
• 3. A simple and convenient synthesis of labeled 9-hydroxy[13C6]phenanthrene as internal standard for mass spectrometry quantification of a key phenanthrene metabolite in human urine, Jean-yves Sancéau, Eric Gaudreau, René Maltais, Donald Poirier Synthetic Communications, 2023.
• 4. A Concise, Gram-Scale Total Synthesis of Protectin DX and Related Labeled Versions via a Key Stereoselective Reduction of Enediyne René Maltais, Jean-Yves Sancéau, Donald Poirier, André Marette, The Journal of Organic Chemistry 2023.
• 5. An Improved Synthesis of Glucuronide Metabolites of Hindered Phenolic Xenoestrogens, Jean-Yves Sancéau, Patrick Bélanger, René Maltais, Donald Poirier, Current Organic Synthesis 2022.
• 6. Total Synthesis of the Antidiabetic (Type 2) Lipid Mediator Protectin DX (PDX) Jean-Yves Sancéau, René Maltais, Donald Poirier, André Marette, Journal Of Organic Chemistry 2018.
• 7. Effect of toremifene and ospemifene, compared to acolbifene, on estrogen-sensitive parameters in rat and human uterine tissues. Fernand Labrie, Sylvain Gauthier, Celine Martel, Jean-Yves Sancéau Hormone Molecular Biology and Clinical Investigation 2009.
• 8. Synthesis and deuterium labelling of the pure selective estrogen receptor modulator (SERM) acolbifene glucuronides. Jean-Yves Sancéau, Denis Larouche, Brigitte Caron, Patrick Bélanger, Agnès Coquet, Alain Bélanger, Fernand Labrie, Sylvain Gauthier, Journal of Labelled Compounds and Radiopharmaceuticals·2007.
• 9. Synthesis of 14C‐labelled EM‐800 (SCH 57050) and EM‐652·HCl (SCH 57068·HCl, acolbifene), pure selective estrogen receptor modulators Jean-Yves Sancéau, Fernand Labrie, Sylvain Gauthier, Journal of Labelled Compounds and Radiopharmaceuticals 2004.
• 10. New Highly Stereoselective Synthesis of (E)-Droloxifene via Selective Protection of 3,4′-Dihydroxybenzophenone and McMurry Reaction Jean-Yves Sancéau, Mailhot Josée, Cloutier Julie, Brigitte Caron, Sylvain Gauthier Tetrahedron, 2000.
• 11. An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase, Stephen Hanessian, Pun-Pin Lu, Jean-Yves Sancéau, Philippe Chemla, Keigo Ghoda, Raymonde Fonne-Pfitser, Lars Prade, Sandra W Cowan-Jacob Angewandte Chemie International Edition 1999.
• 12. Asymmetric synthesis of taxol and taxotère side chains by enolate hydroxylation Stephen Hanessian, Jean-Yves Sancéau Canadian Journal of Chemistry 1996.
• Synthesis of 1-N-Hydroxyhydantoin 5-Phosphates as Potential Fungicides Stephen Hanessian, Rui-Yang Yang, Jean-Yves Sancéau, Canadian Journal of Chemistry 1995.
• 13. Synthesis of surrogate structures related to the herbicidal agent hydantocidin Stephen Hanessian, Jean-Yves Sancéau, Philippe Chemla, Tetrahedron 1995.
• 14. Lignanes. 17. Recherches sur la synthèse totale d'un norcyclonéolignane, la métaséquirine-B Jean-Yves Sancéau, Robert Dhal, Eric Brown, Tetrahedron 1994.
• 15. Asymmetric dihydroxylation of olefins with a simple chiral ligand, Stephen Hanessian, Patrick Meffre, Mario Girard, Yolande Hervé, Jean-Yves Sancéau, Youssef Bennani, Journal of Organic Chemistry 1993.
• 16. Total Synthesis Of (±)-Tetra-O-Methyl-5,8-Bis-Epimetasequirin-B Jean-Yves Sancéau, Robert Dhal, Eric Brown, Natural Products Letters, 1992.