Isabella Sanchez

Supports and coordinates the tasks of clinical research studies:

• Pre-screens, recruits, consents, and schedules appointments with patients/participants
• oversees data and specimen management
• manages renewals and modifications of protocol applications
• helps assure compliance with all relevant regulatory agencies
• maintains all regulatory documents
• implements and maintains periodic quality control procedures
• participates in any internal and external audits or reviews of study protocols

Developed CRISPR gene editing therapies for neurodegenerative diseases (i.e. Frontotemporal dementia and Alzheimer's disease):

• designed/conducted CRISPR guide screens to test which sgRNA pairs are most efficient at excising target DNA sequences
• generated CRISPR edited iPSC cell lines (bi-allelic and allele specific knockouts)
• differentiated iPSC lines into NGN2 neurons
• designed/optimized protein assays (i.e. Western blot, ELISA, JESS, MSD) to measure tau phosphorylation in CRISPR edited iPSC cell lines
• designed/conducted assays to compare phenotypes of various MAPT mutations (IVS10+16, R317W, A152T, V337M)

Berkeley Youth Alternatives (BYA) targets low-income and 'high risk' students in the South and West Berkeley communities. By offering enriching, healthy alternatives in a safe and supervised haven, BYA aims to improve the chances of 'at risk' youth to stay in school and obtain a higher education.

- As an Academic Support Tutor, I led BYA's Afterschool program which included tutoring, recreational activities, health education, crafts, music, computer class, gardening, and dance instruction.

Validated new drug targets for cancer immunotherapies and studied the effects of the autophagic signaling cascade on tumor growth and MHC class 1-mediated antigen processing and presentation