Charles Choi

Very passionate about biology and chemistry knowledge that helps navigate the field of human genomes and human diseases in the future. Keen to contribute to the team and explore my potential. Hardworking and committed to the job. Organized and dependable candidate successful at managing multiple priorities with a positive attitude. Willingness to take on added responsibilities to meet team goals. Availability in summer.

in silico kinase binding site exploration

-This project sets out to understand how a small molecule upregulates kinase activity of several kinases including PAK1 and BMX1. Previous literature suggests the mode of activation of PAK1 to be the release of an autoinhibitory domain and the autophosphorylation of the active loop (Thr423).  With the use of docking software, I am able to find theoretical docking positions that perturb the interaction of the kinase domain with the autoinhibitory domain, leading to the subsequent phosphorylation and kinase activation.