Bo SUN

A highly skilled physician and researcher specializing in Reproductive Medicine, with over seven years of clinical experience in infertility diagnosis, assisted reproductive technologies (IVF/ICSI/PGT/IUI). Currently pursuing a Master’s in Global Health Systems at the University of Western Ontario, integrating reproductive health expertise with global healthcare strategies. Previously served as Assistant Director Physician & Associate Professor at The First Affiliated Hospital of Zhengzhou University, where responsibilities included patient treatment, ultrasound-guided procedures, controlled ovarian hyperstimulation, and mentoring postgraduate students in clinical and research settings. Holds a Ph.D. in Reproductive Medicine from Zhengzhou University and a Joint-Ph.D. in Regenerative Medicine from University Health Network, with research expertise in stem cell-based therapies and reproductive health innovations. With a strong background in clinical practice, academic research, and medical education, committed to advancing reproductive health solutions on a global scale.

· Medical Science and Technology Project of Henan Province-Joint construction project (No.LHGJ20210353) ,01/01/2022-31/12/2023.Supporting amount(¥): 200,000.

- Title: Mesenchymal stem cell-derived exosome miR-223 regulates cellular microenvironment through NHE-1 to improve ovarian function in premature ovarian failure

- Role: Principal Investigator.

· Key project of Medical Science and Technology Project of Henan Province. (No.SBGJ202002049), 01/01/2021-31/12/2022, Supporting amount(¥): 80,000.

- Title: Mechanism of mesenchymal stem cell exosomes Circ-021049 regulating apoptosis of POF mouse granulosus cells through BCL2 pathway

- Role: Principal Investigator.

· Chinese Medical Association Clinical Medical research special fund project. (No.17020190688), 01/12/2017-31/12/2019, Supporting amount(¥): 126,000.

- Title: Regulation and mechanism of TFAP2C in human primordial germ cell development

- Role: Principal Investigator.

· Key Research and development project of Universities in Henan Province. (No.19A320056), 01/01/2019-31/12/2020, Supporting amount(¥): 60,000.

- Title: Regulation of polyploid formation by RNAm6A methylation and its molecular mechanism in cardiomyocytes

- Role: Principal Investigator.

· Medical Science and Technology Project of Henan Province-Joint construction project. (No.2018020116), 01/01/2019-31/12/2020, Supporting amount(¥): 200,000.

- Title: Regulation and mechanism of related genes during human primordial germ cell development

- Role: Principal Investigator.

· Foundation of National Key Program of Research and Development of China. (No.2019YFA0110900), 10/2019-12/2023, Supporting amount(¥): 26,850,000.

- Title: Preclinical research and transformation of cell therapy for primate gonadal failure

- Role: Clinical PI and data analysis.

· The National Natural Science Foundation of China. (No.31471404), 01/2015-12/2018, Supporting amount(¥): 880,000.

- Title: The role and molecular regulation mechanism of EGF-related growth factor in VEGF generation in human ovarian granulosa cells

Role: Research Assistant. Data and sample collection; DNA extraction from whole granulosa cells sample; writing research paper with colleagues

· The Second Prize of 2020 Annual Science and Technology Progress Award in Henan Province(Certificate ID:2020-J-103-R03/07)

· The Second Prize of 2016 Annual Science and Technology Progress Award in Henan Province(Certificate ID:2016-J-112-R08/08)

· The First Prize of 2020 Annual Medical Science and Technology Progress Award in Henan province (Certificate ID: 2020-YJ-043-R03/07).

· The First Prize of 2016 Annual Medical Science and Technology Progress Award in Henan province (Certificate ID: 2016-YJ-003-R08/08)

· Scholarship, National Encouragement Scholarship, National Scholarship and Merit Student, Zhengzhou University, 2007/2008/2009/2010/2011/2012/2013

“Outstanding Graduate student in Henan Province”2011/2013

Hu Linli, Sun Yingpu, Bo Sun, Su Yingchun, Guo Yihong, Zhang Yile. Noninvasive intrauterine irrigation and intrauterine fluid self-positioning sampling device. Chinese Patent, No.CN213219836U, 27/05/2020

· Bo Sun*, Lu Li, Xiaoli Chen. Identification of metabolomic changes and potential therapeutic targets in granulosa cell and follicle fluid of advanced age women. Aging 2024-09-18Aging (Albany NY) 2024 Oct 9;0(19):12893-12908

· Bo Sun, Lu Li, Xiaoli Chen,and Yingpu Sun*. ART pregnancy outcomes in women with premature ovarian insufficiency:A systematic review.Front Endocrinol (Lausanne) 2024;15(0):1343803

· Bo Sun†, Lu Li†, Xiaoli Chen and Yingpu Sun*. Effect of low-molecular-weight heparin in women undergoing frozen-thawed embryo transfer cycles: a retrospective cohort study. BMC Pregnancy Childbirth 2023 May 10;23(1)

· Sun Bo†,Yujia Ma†,Li L,Linli Hu, Fang Wan，Zhang Y,  Dai S,Sun Yingpu*Factors Associated with Ovarian Hyperstimulation Syndrome (OHSS) Severity in Women With Polycystic Ovary Syndrome Undergoing IVF/ICSI. Front Endocrinol (Lausanne) 2020;11

· Sun Bo†, Yujia Ma†, Fang Wang, Linli Hu and Yingpu Sun*. miR-644-5p carried by bone mesenchymal stem cell-derived exosomes targets regulation of p53 to inhibit ovarian granulosa cell apoptosis. Stem Cell Res Ther 2019 Nov 29;10(1)

· Lu Li †, Bo Sun† , Fang Wang, Yile Zhang and Yingpu Sun* Which Factors Are Associated With Reproductive Outcomes of DOR Patients in ART Cycles: An Eight-Year Retrospective Study. Front Endocrinol (Lausanne)23 June 2022

· Lu Li †, Bo Sun† , Yingpu Sun*Identification of functional TF-miRNA-hub gene regulatory network associated with ovarian endometriosis.Front Genet 2022;13

· Linli H†, Bo Sun†, Yujia Ma, Lu Li, Fang Wang, Hao Shi and Yingpu Sun*. The Relationship Between Serum Delta FSH Level and Ovarian Response in IVF/ICSI Cycles. Front Endocrinol (Lausanne) 2021;01

· Fang Wang,Xuemei Chen, Bo Sun, Yujia Ma,Wenbin Niu, Jun Zhai,Yingpu Sun.Hypermethylation-mediated down-regulation of lncRNA PVT1 promotes granulosa cell apoptosis in premature ovarian insufficiency via interacting with Foxo3a. Cell Physiol.2021 Jul;236(7):5162-5175.

· Jing Li, Fuli Zhang, Bo Sun, Shanjun Dai, Qingling Yang, Linli Hu, Hao Shi, Jiawei Xu, Wenbin Niu, Yihong Guo.Lower chromosomal abnormality frequencies in miscarried conceptuses from frozen blastocyst transfers in ART.Hum Reprod.2021 Mar 18;36(4):1146-1156.

· Sun Bo; Yu Wenzhu; Wang Fang; Song Wenyan; Jin Haixia; Sun Yingpu*, Effects of group culture on the development of discarded human embryos and the construction of human embryonic stem cell lines, Journal of Assisted Reproduction and Genetics, 2014.10, 31(10): 1369~1376

· Sun Bo; Wang Fang; Sun Jing; Yu Wenzhu; Sun Yingpu*, Basal serum testosterone levels correlate with ovarian response but do not predict pregnancy outcome in non-PCOS women undergoing IVF, Journal of Assisted Reproduction and Genetics, 2014.7, 31(7): 829~835

· Xu Jiawei; Zhang Meixiang; Niu Wenbin; Yao Guidong; Sun Bo; Bao Xiao; Wang Linlin; Du Linqing; Sun Yingpu*, Genome-wide uniparental disomy screenin human discarded morphologically abnormal embryos, Scientific Reports, 2015.7.21, 5

· Yu Wenzhu;Niu Wenbin;Wang Shuna;Chen Xuemei; Sun Bo; Wang Fang;Sun Yingpu*, Co-culture with endometrial stromal cells enhances the differentiation of human embryonic stem cells into endometrium-like cells, Experimental and Therapeutic Medicine, 2015.7, 10(1): 43~50

· Yu Wenzhu; Chen Xuemei; Niu Wenbin; Wang Fang; Sun Bo; Sun Yingpu*, Role of Wnt5a in the differentiation of human embryonic stem cells into endometrium-like cells, Interbational Journal of Clinical and Experimental Pathology. 2015, 8(5): 5478~5484