Aleksandra María Berenguer Roque

Berenguer A, Osoria L, Gonzalez Suarez N, Manso A,   Salomon S, Padron Yaquis AS, Annabi B and Piloto-Ferrer J. “Exploring   the Potential of Xanthatin from Cuban Xanthium strumarium: Isolation,   Characterization, and Biological Evaluation.” Journal of Biomedical   Research and Environmental Science (2024): 1176-1186.

Dayana Mesa Tejeda, Giselle Hernández Campoalegre, Aleksandra Berenguer Roque, Janet Piloto Ferrer, María Núñez, Yamilet Coll García, Luis Espinoza-Catalán. “Synthesis and   characterization of hydroxymino steroids and their acetates with possible   cytotoxic activity in lung cancer cells”. Manuscript under preparation.

Aleksandra   Berenguer, Alain Zgheib,   Janet Piloto-Ferrer, Borhane Annabi. “Xanthatin nanocrystals exert   anti-inflammatory properties against 2D monolayers and 3D spheroids of a   human HT29 colorectal cancer cell model.” Submitted manuscript

• I International Symposium on Products of Natural Origin CNIC ProNat 2022

Authors: Berenguer, A; Manso, A; Hernandez, D; Machado, A; Villa, A; Fuentes, S; Piloto, J & Sánchez, A. "Evaluation of the cytotoxicity and antitubulin activity of the hydroalcoholic extract of a species of the genus Plectranthus in two tumor lines" . Type of participation: Oral presentation.

Authors: Berenguer, A; Manso, A; Hernandez, D; Osoria, L; Machado, A; Villa, A; Fuentes, S; Piloto, J & Sánchez, A. "Qualitative chemical composition of ethyl acetate extract by UPLC/ESI/IT/MSn and antiproliferative effect of a native Cuban species of the genus Serjania" . Type of participation: Co-author, Guest Delegate.

Authors: Berenguer, A; Manso, A; Hernandez, D; Osoria, L; Machado, A; Villa, A; Fuentes, S; Piloto, J & Sánchez, A. “Antiproliferative effect of hydroalcoholic extracts of a Serjania species on CT26WT and A549 cell lines” .Type of participation: Co-author, Guest Delegate.

Authors: Berenguer, A; Manso, A; Hernandez, D; Osoria, L; Machado, A; Villa, A; Fuentes, S; Piloto, J & Sánchez, A. "Antitubulin activity and cytotoxic effect on carcinoma cell lines from extracts of Urera species" .Type of participation: Co-author, Guest Delegate.

• I International Congress of Cuban Biotechnology, BIOHABANA, Havana, Cuba, 2022. https://eventosencuba.com/bio-habana-2022/

• Oncology Congress. I International Symposium Cuba-Mexico "Thematic panel of Cuban plants”

Authors: Berenguer, A; Manso, A; Hernandez, D; Machado, A; Villa, A; Fuentes, S; Piloto, J & Sánchez, A. "Evaluation of the cytotoxicity and antitubulin activity of the hydroalcoholic extract of a species of the genus Plectranthus in two tumor lines" .Type of participation: Electronic poster

• CIDEM 2022 International Symposium

Authors: Berenguer, A; Manso, A; Hernandez, D; Machado, A; Villa, A; Fuentes, S; Piloto, J & Borhanne, A. "CIDEM 400 induces mitotic arrest and apoptosis in two human tumor cell lines". Type of participation: Speaker, oral presentation

• 5th International Congress on Research, Development and Innovation in the Biopharmaceutical Industry, IDIFARMA 2023

Authors: Berenguer, A; Manso, A; Hernandez, D; Machado, A; Villa, A; Fuentes, S & Piloto, J. “Cancer Models in Preclinical Research: a maze of opportunities and challenges”. Type of participation: Speaker, oral presentation

• IV International Symposium Cancer 2023.

Authors: Berenguer, A; Manso, A; Hernandez, D; Machado, A; Villa, A; Fuentes, S; Pilot, J; Borhanne, A & Francisco, M. “Targeting of Cancer Cell Drug Resistance Phenotype and Metastasis with Xanthium strumarium L. extract”. Type of participation: Speaker, oral presentation

• INNOCANCER 2023: an initiative under ADELANTE 2 for triangular cooperation between Latin America, the Caribbean and the European Union. IV International Symposium Cancer 2023. Guest delegate. https://www.cigb.edu.cu/event/iv-simposio-internacional-cancer-2023/.

• International Congress on Pharmacology of Natural Products. FAPRONATURA 2024

Authors: Berenguer, A; Manso, A; Hernandez, D; Machado, A; Villa, A; Fuentes, S; Pilot, J; Borhanne, A & Francisco, M. “Xanthatins from Xanthium strumarium L. extract can effectively target mestastasis and resistance in an ovarian cancer model”. Type of participation: Speaker, oral presentation

Emerging  Leaders in the Americas Program (ELAP) scholarship 2024-25, funded by Global Affairs Canada.  Research  internship at the Department of Chemistry and Biochemistry of the Université du Québec à Montréal (UQAM)

Inventors: Pilot, J; Solomon, S; Manso,   A; Berenguer, A; Osoria, L & Borhanne, A.

Title: “Pharmaceutical compositions   of nanocrystallized xanthatin and its uses as an antitumor”

Application number: Invention Patent   Application.

Application submitted to the   Cuban Intellectual Property Office (OCPI) on 11/06/2023. Priority country:   Cuba

Owner entity: Center for Pharmaceutical Research and Development, BioCubaFarma.

Division of Experimental Oncology and Toxicology (CIDEM)

• Seminar speaker: “Ames test for mutagenicity assessment: principle, procedure, uses and interpretation of results”
• Opposition to an undergraduate work thesis in Biology entitled: "Effect of the immunomodulatory peptide CIGB-814 (Jusvinza) on the hematological parameters of reproductive toxicity”. [2024].
• Mentoring of undergraduate students in laboratory techniques concerning the biological evaluation of secondary metabolites ans synthetic molecules, as well as laboratory protocols and cell culture procedures.

2022-present

• “Development of multifunctional xanthatin-releasing nanoplatforms for cancer therapy” (Leading Inst.: CIDEM)

Report of results approved   by the scientific board of CIDEM, entitled: Isolation and characterisation of   xanthatin from the aerial parts of Xanthium   chinense Mill.

• “Natural products as a source of agents useful in the chemoprevention and chemotreatment of UV-induced conditions” (Leading Inst.: Department of Biology, UH).
• “Effect of xanthatins in combination with conventional cytostatics used in colon cancer therapy” (Leading Inst.: CIDEM)
• “Functionalization of polymeric nanoparticles of antitumor drugs with monoclonal antibodies for targeted cancer therapy” (Leading Inst.: CIDEM)
• Development of folic acid-functionalized chitosan-coated polymeric antitumor nanoparticles for targeted cancer therapy. (Leading Inst.: CIDEM)
• “Chemical study of the bark of Serjania subdentata Juss. ex Radlk. Antibacterial activity and preliminary toxicity tests” presented as a BSc Chemistry project. Department of Organic Chemistry. Faculty of Chemistry. Faculty of Chemystry. UH

• Toxicological Genetics. Faculty of Biology, University of Havana [08/11/2023 – 04/12/2023]
• Nanomaterials, medical imaging and nanoparticles for health applications. Faculty of Chemistry, University of Havana [11/29/2023 – 12/01/2023]

1ére École d'Hiver en Oncologie de Précision, 2025

Orford Jouvence,QC

Related Fields: Molecular imaging, immunotherapy, multi-omics